TY - JOUR
T1 - Identification and characterization of Mlr1,2
T2 - Two mouse homologues of Mblk-1, a transcription factor from the honeybee brain
AU - Kunieda, Takekazu
AU - Park, Jung Min
AU - Takeuchi, Hideaki
AU - Kubo, Takeo
AU - Gojobori, Takashi
PY - 2003/1/30
Y1 - 2003/1/30
N2 - We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.
AB - We previously identified the Mblk-1 gene in the honeybee brain, which encodes a transcription factor containing two DNA binding motifs, termed RHF1 and 2 (Takeuchi et al. (2001) Insect Mol. Biol. 121, 134-140). Here, we identified two mouse Mblk1 homologues, Mlr1 and Mlr2. Both encode proteins containing a single DNA-binding motif highly conserved with RHF2 and activate transcription mediated by a DNA element recognized by honeybee Mblk-1. Mlr1 was expressed predominantly in the spermatocytes of the testis, while Mlr2 was expressed in various tissues other than testis. Mlr1 transcripts were lost in the testis of W/Wv mutant mice, suggesting a role in spermatogenesis.
UR - http://www.scopus.com/inward/record.url?scp=0037472653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037472653&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(02)03858-9
DO - 10.1016/S0014-5793(02)03858-9
M3 - Article
C2 - 12560079
AN - SCOPUS:0037472653
SN - 0014-5793
VL - 535
SP - 61
EP - 65
JO - FEBS Letters
JF - FEBS Letters
IS - 1-3
ER -