Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

T. D. Bartley; J. Bogenberger; P. Hunt; Y. S. Li; H. S. Lu; F. Martin; M. S. Chang; B. Samal; J. L. Nichol; S. Swift; M. J. Johnson; R. Y. Hsu; V. P. Parker; S. Suggs; J. D. Skrine; L. A. Merewether; C. Clogston; E. Hsu; M. M. Hokom; A. Hornkohl; E. Choi; M. Pangelinan; Y. Sun; V. Mar; J. McNinch; L. Simonet; F. Jacobsen; C. Xie; J. Shutter; H. Chute; R. Basu; L. Selander; D. Trollinger; L. Sieu; D. Padilla; G. Trail; G. Elliott; R. Izumi; T. Covey; J. Crouse; A. Garcia; W. Xu; J. Del Castillo; J. Biron; S. Cole; M. C.T. Hu; R. Pacifici; I. Ponting; C. Saris; D. Wen; Y. P. Yung; H. Lin; R. A. Rosselman

doi:10.1016/0092-8674(94)90450-2

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

T. D. Bartley, J. Bogenberger, P. Hunt, Y. S. Li, H. S. Lu, F. Martin, M. S. Chang, B. Samal, J. L. Nichol, S. Swift, M. J. Johnson, R. Y. Hsu, V. P. Parker, S. Suggs, J. D. Skrine, L. A. Merewether, C. Clogston, E. Hsu, M. M. Hokom, A. HornkohlE. Choi, M. Pangelinan, Y. Sun, V. Mar, J. McNinch, L. Simonet, F. Jacobsen, C. Xie, J. Shutter, H. Chute, R. Basu, L. Selander, D. Trollinger, L. Sieu, D. Padilla, G. Trail, G. Elliott, R. Izumi, T. Covey, J. Crouse, A. Garcia, W. Xu, J. Del Castillo, J. Biron, S. Cole, M. C.T. Hu, R. Pacifici, I. Ponting, C. Saris, D. Wen, Y. P. Yung, H. Lin, R. A. Rosselman

Department of Biochemistry and Molecular Biology

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945 Citations (Scopus)

Abstract

A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine, and human sources. Purified canine MGDF isolated by procedures involving MpI receptor affinity chromatography exists in at least two forms, with apparent molecular masses of 25 kDa and 31 kDa, that share the N-terminal amino acid sequence APP-ACDPRLLNKMLRDSHVLH. Human, dog, and mouse cDNAs for MGDF are highly conserved and encode open reading frames for proteins of 353, 352, and 356 amino acids, respectively, including predicted signal peptides. Canine MGDF and recombinant human MGDF support the development of megakaryocytes from human CD34⁺ progenitor cell populations in liquid culture and promote the survival of a factor-dependent murine cell line (32D) engineered to express MpI. These biological activities are blocked by the soluble extracellular domain of MpI. These data demonstrate that MGDF is a novel cytokine that regulates megakaryocyte development and is a ligand for the MPI receptor.

Original language	English
Pages (from-to)	1117-1124
Number of pages	8
Journal	Cell
Volume	77
Issue number	7
DOIs	https://doi.org/10.1016/0092-8674(94)90450-2
Publication status	Published - 1994 Jul 1

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

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10.1016/0092-8674(94)90450-2

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Bartley, T. D., Bogenberger, J., Hunt, P., Li, Y. S., Lu, H. S., Martin, F., Chang, M. S., Samal, B., Nichol, J. L., Swift, S., Johnson, M. J., Hsu, R. Y., Parker, V. P., Suggs, S., Skrine, J. D., Merewether, L. A., Clogston, C., Hsu, E., Hokom, M. M., ... Rosselman, R. A. (1994). Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI. Cell, 77(7), 1117-1124. https://doi.org/10.1016/0092-8674(94)90450-2

@article{f8bbe93b501346afaade9f2ef3d7dc34,

title = "Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI",

abstract = "A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine, and human sources. Purified canine MGDF isolated by procedures involving MpI receptor affinity chromatography exists in at least two forms, with apparent molecular masses of 25 kDa and 31 kDa, that share the N-terminal amino acid sequence APP-ACDPRLLNKMLRDSHVLH. Human, dog, and mouse cDNAs for MGDF are highly conserved and encode open reading frames for proteins of 353, 352, and 356 amino acids, respectively, including predicted signal peptides. Canine MGDF and recombinant human MGDF support the development of megakaryocytes from human CD34+ progenitor cell populations in liquid culture and promote the survival of a factor-dependent murine cell line (32D) engineered to express MpI. These biological activities are blocked by the soluble extracellular domain of MpI. These data demonstrate that MGDF is a novel cytokine that regulates megakaryocyte development and is a ligand for the MPI receptor.",

author = "Bartley, {T. D.} and J. Bogenberger and P. Hunt and Li, {Y. S.} and Lu, {H. S.} and F. Martin and Chang, {M. S.} and B. Samal and Nichol, {J. L.} and S. Swift and Johnson, {M. J.} and Hsu, {R. Y.} and Parker, {V. P.} and S. Suggs and Skrine, {J. D.} and Merewether, {L. A.} and C. Clogston and E. Hsu and Hokom, {M. M.} and A. Hornkohl and E. Choi and M. Pangelinan and Y. Sun and V. Mar and J. McNinch and L. Simonet and F. Jacobsen and C. Xie and J. Shutter and H. Chute and R. Basu and L. Selander and D. Trollinger and L. Sieu and D. Padilla and G. Trail and G. Elliott and R. Izumi and T. Covey and J. Crouse and A. Garcia and W. Xu and {Del Castillo}, J. and J. Biron and S. Cole and Hu, {M. C.T.} and R. Pacifici and I. Ponting and C. Saris and D. Wen and Yung, {Y. P.} and H. Lin and Rosselman, {R. A.}",

year = "1994",

month = jul,

day = "1",

doi = "10.1016/0092-8674(94)90450-2",

language = "English",

volume = "77",

pages = "1117--1124",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "7",

}

Bartley, TD, Bogenberger, J, Hunt, P, Li, YS, Lu, HS, Martin, F, Chang, MS, Samal, B, Nichol, JL, Swift, S, Johnson, MJ, Hsu, RY, Parker, VP, Suggs, S, Skrine, JD, Merewether, LA, Clogston, C, Hsu, E, Hokom, MM, Hornkohl, A, Choi, E, Pangelinan, M, Sun, Y, Mar, V, McNinch, J, Simonet, L, Jacobsen, F, Xie, C, Shutter, J, Chute, H, Basu, R, Selander, L, Trollinger, D, Sieu, L, Padilla, D, Trail, G, Elliott, G, Izumi, R, Covey, T, Crouse, J, Garcia, A, Xu, W, Del Castillo, J, Biron, J, Cole, S, Hu, MCT, Pacifici, R, Ponting, I, Saris, C, Wen, D, Yung, YP, Lin, H & Rosselman, RA 1994, 'Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI', Cell, vol. 77, no. 7, pp. 1117-1124. https://doi.org/10.1016/0092-8674(94)90450-2

TY - JOUR

T1 - Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

AU - Bartley, T. D.

AU - Bogenberger, J.

AU - Hunt, P.

AU - Li, Y. S.

AU - Lu, H. S.

AU - Martin, F.

AU - Chang, M. S.

AU - Samal, B.

AU - Nichol, J. L.

AU - Swift, S.

AU - Johnson, M. J.

AU - Hsu, R. Y.

AU - Parker, V. P.

AU - Suggs, S.

AU - Skrine, J. D.

AU - Merewether, L. A.

AU - Clogston, C.

AU - Hsu, E.

AU - Hokom, M. M.

AU - Hornkohl, A.

AU - Choi, E.

AU - Pangelinan, M.

AU - Sun, Y.

AU - Mar, V.

AU - McNinch, J.

AU - Simonet, L.

AU - Jacobsen, F.

AU - Xie, C.

AU - Shutter, J.

AU - Chute, H.

AU - Basu, R.

AU - Selander, L.

AU - Trollinger, D.

AU - Sieu, L.

AU - Padilla, D.

AU - Trail, G.

AU - Elliott, G.

AU - Izumi, R.

AU - Covey, T.

AU - Crouse, J.

AU - Garcia, A.

AU - Xu, W.

AU - Del Castillo, J.

AU - Biron, J.

AU - Cole, S.

AU - Hu, M. C.T.

AU - Pacifici, R.

AU - Ponting, I.

AU - Saris, C.

AU - Wen, D.

AU - Yung, Y. P.

AU - Lin, H.

AU - Rosselman, R. A.

PY - 1994/7/1

Y1 - 1994/7/1

N2 - A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine, and human sources. Purified canine MGDF isolated by procedures involving MpI receptor affinity chromatography exists in at least two forms, with apparent molecular masses of 25 kDa and 31 kDa, that share the N-terminal amino acid sequence APP-ACDPRLLNKMLRDSHVLH. Human, dog, and mouse cDNAs for MGDF are highly conserved and encode open reading frames for proteins of 353, 352, and 356 amino acids, respectively, including predicted signal peptides. Canine MGDF and recombinant human MGDF support the development of megakaryocytes from human CD34+ progenitor cell populations in liquid culture and promote the survival of a factor-dependent murine cell line (32D) engineered to express MpI. These biological activities are blocked by the soluble extracellular domain of MpI. These data demonstrate that MGDF is a novel cytokine that regulates megakaryocyte development and is a ligand for the MPI receptor.

AB - A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine, and human sources. Purified canine MGDF isolated by procedures involving MpI receptor affinity chromatography exists in at least two forms, with apparent molecular masses of 25 kDa and 31 kDa, that share the N-terminal amino acid sequence APP-ACDPRLLNKMLRDSHVLH. Human, dog, and mouse cDNAs for MGDF are highly conserved and encode open reading frames for proteins of 353, 352, and 356 amino acids, respectively, including predicted signal peptides. Canine MGDF and recombinant human MGDF support the development of megakaryocytes from human CD34+ progenitor cell populations in liquid culture and promote the survival of a factor-dependent murine cell line (32D) engineered to express MpI. These biological activities are blocked by the soluble extracellular domain of MpI. These data demonstrate that MGDF is a novel cytokine that regulates megakaryocyte development and is a ligand for the MPI receptor.

UR - http://www.scopus.com/inward/record.url?scp=0028343099&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028343099&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(94)90450-2

DO - 10.1016/0092-8674(94)90450-2

M3 - Article

C2 - 8020099

AN - SCOPUS:0028343099

SN - 0092-8674

VL - 77

SP - 1117

EP - 1124

JO - Cell

JF - Cell

IS - 7

ER -

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

Abstract

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