Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats

A. Min Huang; Eminy H.Y. Lee

doi:10.1097/00001756-199705060-00013

Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats

A. Min Huang, Eminy H.Y. Lee

Department of Physiology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Using the polymerase chain reaction (PCR) differential display directed to cloning transcripts related to retention performance for the inhibitory avoidance learning task, we have isolated two rat cDNA fragments homologous to the 3' untranslated region (3'UTR) of glial fibrillary acid protein (GFAP) cDNA. The GFAP upper cDNA represents a new GFAP mRNA isotype which has a 7 bp insertion in the 3'UTR. Further analyses indicated that retention performance in rats containing only the new GFAP mRNA isotype was significantly better than that of rats containing both the new GFAP mRNA isotype and the standard GFAP mRNA simultaneously. These results suggest that expression of the GFAP isotypes may be related to memory retention in rats.

Original language	English
Pages (from-to)	1619-1624
Number of pages	6
Journal	NeuroReport
Volume	8
Issue number	7
DOIs	https://doi.org/10.1097/00001756-199705060-00013
Publication status	Published - 1997 Jan 1

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1097/00001756-199705060-00013

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abstract = "Using the polymerase chain reaction (PCR) differential display directed to cloning transcripts related to retention performance for the inhibitory avoidance learning task, we have isolated two rat cDNA fragments homologous to the 3' untranslated region (3'UTR) of glial fibrillary acid protein (GFAP) cDNA. The GFAP upper cDNA represents a new GFAP mRNA isotype which has a 7 bp insertion in the 3'UTR. Further analyses indicated that retention performance in rats containing only the new GFAP mRNA isotype was significantly better than that of rats containing both the new GFAP mRNA isotype and the standard GFAP mRNA simultaneously. These results suggest that expression of the GFAP isotypes may be related to memory retention in rats.",

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AB - Using the polymerase chain reaction (PCR) differential display directed to cloning transcripts related to retention performance for the inhibitory avoidance learning task, we have isolated two rat cDNA fragments homologous to the 3' untranslated region (3'UTR) of glial fibrillary acid protein (GFAP) cDNA. The GFAP upper cDNA represents a new GFAP mRNA isotype which has a 7 bp insertion in the 3'UTR. Further analyses indicated that retention performance in rats containing only the new GFAP mRNA isotype was significantly better than that of rats containing both the new GFAP mRNA isotype and the standard GFAP mRNA simultaneously. These results suggest that expression of the GFAP isotypes may be related to memory retention in rats.

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Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats

Abstract

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