Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats

A-Min Huang, Eminy H.Y. Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Using the polymerase chain reaction (PCR) differential display directed to cloning transcripts related to retention performance for the inhibitory avoidance learning task, we have isolated two rat cDNA fragments homologous to the 3' untranslated region (3'UTR) of glial fibrillary acid protein (GFAP) cDNA. The GFAP upper cDNA represents a new GFAP mRNA isotype which has a 7 bp insertion in the 3'UTR. Further analyses indicated that retention performance in rats containing only the new GFAP mRNA isotype was significantly better than that of rats containing both the new GFAP mRNA isotype and the standard GFAP mRNA simultaneously. These results suggest that expression of the GFAP isotypes may be related to memory retention in rats.

Original languageEnglish
Pages (from-to)1619-1624
Number of pages6
JournalNeuroReport
Volume8
Issue number7
DOIs
Publication statusPublished - 1997 Jan 1

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Glial Fibrillary Acidic Protein
Messenger RNA
Complementary DNA
3' Untranslated Regions
Avoidance Learning
Retention (Psychology)
Organism Cloning
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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Identification of a novel glial fibrillary acidic protein mRNA isotype related to memory retention in rats. / Huang, A-Min; Lee, Eminy H.Y.

In: NeuroReport, Vol. 8, No. 7, 01.01.1997, p. 1619-1624.

Research output: Contribution to journalArticle

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