Identification of a plasmid encoding SHV-12, TEM-1, and a variant of IMP-2 metallo-β-lactamase, IMP-8, from a clinical isolate of Klebsiella pneumoniae

J. J. Yan, W. C. Ko, J. J. Wu

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)

Abstract

A multidrug-resistant plasmid encoding TEM-1, SHV-12, and a variant of IMP-2 metallo-β-lactamase, designated IMP-8, was identified from a clinical isolate of Klebsiella pneumoniae. There are four nucleotide differences between blaIMP-2 and blaIMP-8, resulting in two amino acid differences. blaIMP-8 was also found to be carried by an integron-borne gene cassette similar to the blaIMP-2 cassette.

Original languageEnglish
Pages (from-to)2368-2371
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number8
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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