Identification of Escherichia coli genes associated with urinary tract infections

Bin Hsu Mao, Yung Fu Chang, Joy Scaria, Chih Ching Chang, Li Wei Chou, Ni Tien, Jiunn Jong Wu, Chin Chung Tseng, Ming Cheng Wang, Chao Chin Chang, Yuan Man Hsu, Ching Hao Teng

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Escherichia coli is the most common cause of urinary tract infections (UTIs). E. coli genes epidemiologically associated with UTIs are potentially valuable in developing strategies for treating and/or preventing such infections as well as differentiating uropathogenic E. coli from nonuropathogenic E. coli. To identify E. coli genes associated with UTIs in humans, we combined microarray-based and PCR-based analyses to investigate different E. coli source groups derived from feces of healthy humans and from patients with cystitis, pyelonephritis, or urosepsis. The cjrABC-senB gene cluster, sivH, sisA, sisB, eco274, and fbpB, were identified to be associated with UTIs. Of these, cjrABC-senB, sisA, sisB, and fbpB are known to be involved in urovirulence in the mouse model of ascending UTI. Our results provide evidence to support their roles as urovirulence factors in human UTIs. In addition, the newly identified UTI-associated genes were mainly found in members of phylogenetic groups B2 and/or D.

Original languageEnglish
Pages (from-to)449-456
Number of pages8
JournalJournal of Clinical Microbiology
Issue number2
Publication statusPublished - 2012 Feb

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)


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