Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer

Wu Wei Lai, Fen Fen Chen, Ming Ho Wu, Nan Haw Chow, Wu Chou Su, Mi Chia Ma, Pei Fang Su, Helen Chen, Mu Yen Lin, Yau Lin Tseng

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence. Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer. Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence. Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.

Original languageEnglish
Pages (from-to)1868-1876
Number of pages9
JournalAnnals of Thoracic Surgery
Volume72
Issue number6
DOIs
Publication statusPublished - 2001 Dec 1

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Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Recurrence
Neoplasms
Tumor Biomarkers
Embolism
Lung Neoplasms
Immunohistochemistry
Regression Analysis
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer",
abstract = "Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence. Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer. Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence. Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.",
author = "Lai, {Wu Wei} and Chen, {Fen Fen} and Wu, {Ming Ho} and Chow, {Nan Haw} and Su, {Wu Chou} and Ma, {Mi Chia} and Su, {Pei Fang} and Helen Chen and Lin, {Mu Yen} and Tseng, {Yau Lin}",
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Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer. / Lai, Wu Wei; Chen, Fen Fen; Wu, Ming Ho; Chow, Nan Haw; Su, Wu Chou; Ma, Mi Chia; Su, Pei Fang; Chen, Helen; Lin, Mu Yen; Tseng, Yau Lin.

In: Annals of Thoracic Surgery, Vol. 72, No. 6, 01.12.2001, p. 1868-1876.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunohistochemical analysis of epidermal growth factor receptor family members in stage I non-small cell lung cancer

AU - Lai, Wu Wei

AU - Chen, Fen Fen

AU - Wu, Ming Ho

AU - Chow, Nan Haw

AU - Su, Wu Chou

AU - Ma, Mi Chia

AU - Su, Pei Fang

AU - Chen, Helen

AU - Lin, Mu Yen

AU - Tseng, Yau Lin

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence. Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer. Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence. Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.

AB - Background. To elucidate the relationship between the expression of epidermal growth factor receptor family members (ErbB-1, neu/ErbB-2, ErbB-3, and ErbB-4) and tumor recurrence. Methods. We used immunohistochemistry to examine the expression of four epidermal growth factor receptor family members in 73 patients with stage I non-small cell lung cancer. Results. Using Cox univariate analysis, we determined that angiolymphatic tumor emboli and non-well-differentiated tumor cells were two significant conventional pathologic predictors of tumor recurrence, and that ErbB-1 and ErbB-3 were also significant predictors. Co-expression of ErbB-1+, -3+, or expression of three or more epidermal growth factor receptor family members had a significant effect on lung cancer recurrence. A stepwise multivariate Cox proportional hazards regression analysis provided a predictive model for tumor recurrence. Conclusions. The present study shows that in patients with a non-well-differentiated tumor, overexpression of ErbB-3 is a useful marker for predicting tumor recurrence. The present study also confirmed that ErbB-1 expression increased in proportion to the loss of tumor differentiation. The correlation between ErbB-3 and distant metastasis was good.

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