Immunomodulatory activity of various fractions derived from Physalis angulata L extract.

Yee-Shin Lin, H. C. Chiang, W. S. Kan, E. Hone, S. J. Shih, M. H. Won

Research output: Contribution to journalArticle

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Abstract

The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.

Original languageEnglish
Pages (from-to)233-243
Number of pages11
JournalAmerican Journal of Chinese Medicine
Volume20
Issue number3-4
Publication statusPublished - 1992 Dec 1

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Physalis
Antibody Formation
Inbred C3H Mouse
Phytohemagglutinins
Lymphocyte Activation
Lipopolysaccharides
B-Lymphocytes
Cell Proliferation
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine

Cite this

Lin, Y-S., Chiang, H. C., Kan, W. S., Hone, E., Shih, S. J., & Won, M. H. (1992). Immunomodulatory activity of various fractions derived from Physalis angulata L extract. American Journal of Chinese Medicine, 20(3-4), 233-243.
Lin, Yee-Shin ; Chiang, H. C. ; Kan, W. S. ; Hone, E. ; Shih, S. J. ; Won, M. H. / Immunomodulatory activity of various fractions derived from Physalis angulata L extract. In: American Journal of Chinese Medicine. 1992 ; Vol. 20, No. 3-4. pp. 233-243.
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abstract = "The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.",
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Lin, Y-S, Chiang, HC, Kan, WS, Hone, E, Shih, SJ & Won, MH 1992, 'Immunomodulatory activity of various fractions derived from Physalis angulata L extract.', American Journal of Chinese Medicine, vol. 20, no. 3-4, pp. 233-243.

Immunomodulatory activity of various fractions derived from Physalis angulata L extract. / Lin, Yee-Shin; Chiang, H. C.; Kan, W. S.; Hone, E.; Shih, S. J.; Won, M. H.

In: American Journal of Chinese Medicine, Vol. 20, No. 3-4, 01.12.1992, p. 233-243.

Research output: Contribution to journalArticle

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AU - Lin, Yee-Shin

AU - Chiang, H. C.

AU - Kan, W. S.

AU - Hone, E.

AU - Shih, S. J.

AU - Won, M. H.

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N2 - The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.

AB - The immunomodulatory effects of Physalis angulata L. extract fraction VII (PA-VII), PA-VII-A, PA-VII-B and PA-VII-C were investigated in this study. The results showed that PA-VII and PA-VII-C strongly enhanced blastogenesis response, PA-VII-B had moderate activity, and PA-VII-A exerted only slight effect on cell proliferation. A synergistic effect was observed when the suboptimal dosage of phytohemagglutinin (PHA) or lipopolysaccharide (LPS) was added to the culture. Furthermore, PA-VII and PA-VII-C possessed stimulatory activity on B cells and less effect on T cells. The antibody responses were also augmented by PA-VII, PA-VII-B and PA-VII-C, but not by PA-VII-A. The enhancement of antibody response could be observed both in BALB/c and C3H/HeJ mice.

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