Immunomodulatory effects of acute exercise bout in sedentary and trained rats

Yee Shin Lin, Ming Shiou Jan, Tyre Jane Tsai, Hsiun Ing Chen

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


The immune response to acute exercise after long-term training was evaluated in rats. After 10 wk of exercise training on a drum exerciser, both sedentary control and trained groups ran with the intensity of 70% of peak oxygen consumption (VO2peak) for 10 min immediately before sacrifice. The mitogenic activity of spleen lymphocytes in trained group to staphylococcal enterotoxin B, a polyclonal T cell activator, decreased as compared to the sedentary control following acute exercise. However, proliferative response to lipopolysaccharide, a B cell mitogen, was augmented. Furthermore, the interleukin-2 production was reduced in the trained group. The lymphocyte subpopulations in the spleen and the peripheral blood lymphocytes were analyzed by flow cytometry. Although the tendency of changes in some populations was observed in trained vs untrained groups, no statistically significant difference was manifested. The serum levels of both norepinephrine and epinephrine increased immediately after acute exercise. The increase in serum lactate concentration was observed following acute exercise in sedentary control, but less prominent in the trained group.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalMedicine and science in sports and exercise
Issue number1
Publication statusPublished - 1995 Jan

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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