Immunomodulatory effects of acute exercise bout in sedentary and trained rats

Yee-Shin Lin, Ming Shiou Jan, Tyre Jane Tsai, Hsiun Ing Chen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The immune response to acute exercise after long-term training was evaluated in rats. After 10 wk of exercise training on a drum exerciser, both sedentary control and trained groups ran with the intensity of 70% of peak oxygen consumption (VO2peak) for 10 min immediately before sacrifice. The mitogenic activity of spleen lymphocytes in trained group to staphylococcal enterotoxin B, a polyclonal T cell activator, decreased as compared to the sedentary control following acute exercise. However, proliferative response to lipopolysaccharide, a B cell mitogen, was augmented. Furthermore, the interleukin-2 production was reduced in the trained group. The lymphocyte subpopulations in the spleen and the peripheral blood lymphocytes were analyzed by flow cytometry. Although the tendency of changes in some populations was observed in trained vs untrained groups, no statistically significant difference was manifested. The serum levels of both norepinephrine and epinephrine increased immediately after acute exercise. The increase in serum lactate concentration was observed following acute exercise in sedentary control, but less prominent in the trained group.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalMedicine and science in sports and exercise
Volume27
Issue number1
Publication statusPublished - 1995 Jan 1

Fingerprint

Exercise
Spleen
Lymphocytes
Lymphocyte Subsets
Serum
Mitogens
Oxygen Consumption
Epinephrine
Interleukin-2
Lactic Acid
Norepinephrine
Flow Cytometry
B-Lymphocytes
T-Lymphocytes
Control Groups
Population

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Lin, Yee-Shin ; Jan, Ming Shiou ; Tsai, Tyre Jane ; Chen, Hsiun Ing. / Immunomodulatory effects of acute exercise bout in sedentary and trained rats. In: Medicine and science in sports and exercise. 1995 ; Vol. 27, No. 1. pp. 73-78.
@article{0777e2e09e2a4f4baeee9e454712febd,
title = "Immunomodulatory effects of acute exercise bout in sedentary and trained rats",
abstract = "The immune response to acute exercise after long-term training was evaluated in rats. After 10 wk of exercise training on a drum exerciser, both sedentary control and trained groups ran with the intensity of 70{\%} of peak oxygen consumption (VO2peak) for 10 min immediately before sacrifice. The mitogenic activity of spleen lymphocytes in trained group to staphylococcal enterotoxin B, a polyclonal T cell activator, decreased as compared to the sedentary control following acute exercise. However, proliferative response to lipopolysaccharide, a B cell mitogen, was augmented. Furthermore, the interleukin-2 production was reduced in the trained group. The lymphocyte subpopulations in the spleen and the peripheral blood lymphocytes were analyzed by flow cytometry. Although the tendency of changes in some populations was observed in trained vs untrained groups, no statistically significant difference was manifested. The serum levels of both norepinephrine and epinephrine increased immediately after acute exercise. The increase in serum lactate concentration was observed following acute exercise in sedentary control, but less prominent in the trained group.",
author = "Yee-Shin Lin and Jan, {Ming Shiou} and Tsai, {Tyre Jane} and Chen, {Hsiun Ing}",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "27",
pages = "73--78",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

Immunomodulatory effects of acute exercise bout in sedentary and trained rats. / Lin, Yee-Shin; Jan, Ming Shiou; Tsai, Tyre Jane; Chen, Hsiun Ing.

In: Medicine and science in sports and exercise, Vol. 27, No. 1, 01.01.1995, p. 73-78.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Immunomodulatory effects of acute exercise bout in sedentary and trained rats

AU - Lin, Yee-Shin

AU - Jan, Ming Shiou

AU - Tsai, Tyre Jane

AU - Chen, Hsiun Ing

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The immune response to acute exercise after long-term training was evaluated in rats. After 10 wk of exercise training on a drum exerciser, both sedentary control and trained groups ran with the intensity of 70% of peak oxygen consumption (VO2peak) for 10 min immediately before sacrifice. The mitogenic activity of spleen lymphocytes in trained group to staphylococcal enterotoxin B, a polyclonal T cell activator, decreased as compared to the sedentary control following acute exercise. However, proliferative response to lipopolysaccharide, a B cell mitogen, was augmented. Furthermore, the interleukin-2 production was reduced in the trained group. The lymphocyte subpopulations in the spleen and the peripheral blood lymphocytes were analyzed by flow cytometry. Although the tendency of changes in some populations was observed in trained vs untrained groups, no statistically significant difference was manifested. The serum levels of both norepinephrine and epinephrine increased immediately after acute exercise. The increase in serum lactate concentration was observed following acute exercise in sedentary control, but less prominent in the trained group.

AB - The immune response to acute exercise after long-term training was evaluated in rats. After 10 wk of exercise training on a drum exerciser, both sedentary control and trained groups ran with the intensity of 70% of peak oxygen consumption (VO2peak) for 10 min immediately before sacrifice. The mitogenic activity of spleen lymphocytes in trained group to staphylococcal enterotoxin B, a polyclonal T cell activator, decreased as compared to the sedentary control following acute exercise. However, proliferative response to lipopolysaccharide, a B cell mitogen, was augmented. Furthermore, the interleukin-2 production was reduced in the trained group. The lymphocyte subpopulations in the spleen and the peripheral blood lymphocytes were analyzed by flow cytometry. Although the tendency of changes in some populations was observed in trained vs untrained groups, no statistically significant difference was manifested. The serum levels of both norepinephrine and epinephrine increased immediately after acute exercise. The increase in serum lactate concentration was observed following acute exercise in sedentary control, but less prominent in the trained group.

UR - http://www.scopus.com/inward/record.url?scp=0028831301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028831301&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 73

EP - 78

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 1

ER -