Immunostimulation by Alsophila spinulosa extract fraction VII of both humoral and cellular immune responses

S. F. Kao, H. L. Kuo, Y. C. Lee, H. C. Chiang, Y. S. Lin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Alsophila spinulosa (Cyatheaceae) has been used in Asia as a herbal medicine, In this study, the immunomodulatory effects of Alsophila spinulosa dried sterns water extract fraction VII (AS-VII) were studied in vitro using an animal model. The results showed that AS-VII stimulated splenocyte proliferation in both BALB/c and C3H/HeJ mice. By cell fractionation analysis, the results showed that the mitogenic effect of AS-VII was predominantly on B cell population. The antibody response was also augmented by AS-VII in BALB/c and C3H/HeJ mice. The augmentation of immune responses in C3H/HeJ, the lipopolysaccharide (LPS)-hyporesponsive mouse strain, indicated that the activity was not simply due to the LPS contamination which may be present in AS-VII preparation. Furthermore, AS-VII caused an increase in cytotoxic T cell activity in a mixed lymphocyte reaction culture. These data indicate that AS-VII possesses the capability of augmenting both humoral and cellular immune responses.

Original languageEnglish
Pages (from-to)2439-2443
Number of pages5
JournalAnticancer research
Volume14
Issue number6 B
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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