Impact of platelet volume on the clinical outcomes of patients with acute coronary syndrome

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Abstract

Background: Platelets with high hemostatic activity play an important role in the pathophysiology of acute coronary syndrome (ACS), and mean platelet volume (MPV) has been proposed to be an indicator of platelet reactivity. We evaluated the predictive value of MPV and the responsive value of MPV with different antiplatelet agents in association with the clinical outcomes of ACS patients. Methods: A total of 1094 patients with ACS and 472 patients without ACS were included. Blood samples were taken at hospital admission, at routine follow-up within one year, and beyond one year. The patients were divided into a “high MPV group” (> 9.0 fl, n = 305), “medium MPV group” (7.9-9.0 fl, n = 517), and “low MPV group” (< 7.9 fl, n = 272). The average follow-up time was 2.4 years, and the endpoints were major adverse cardiovascular events (MACEs) including all-cause mortality, time to recurrent ACS, target vessel re-intervention and stroke. Results: MPV was significantly higher in the patients with ACS than in those without ACS (8.6 ± 1.1 vs. 8.4 ± 1.0 fl, p = 0.007). MPV decreased in the following year (8.38 ± 1.02 fl, p < 0.001) and also beyond one year (8.38 ± 0.94 fl, p < 0.001) after ACS events. The changes in MPV were not significantly different between the patients receiving either clopidogrel or ticagrelor. The high MPV group had more cardiovascular risk factors and more MACEs than the low MPV group (p = 0.017). Conclusions: A higher MPV in patients with ACS was associated with more cardiovascular risk factors and more cardiovascular events during clinical follow-up.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalActa Cardiologica Sinica
Volume35
Issue number6
DOIs
Publication statusPublished - 2019 Jan 1

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Mean Platelet Volume
Acute Coronary Syndrome
Blood Platelets
clopidogrel
Platelet Aggregation Inhibitors
Hemostatics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{84856910183c456393501b2aedeab9bc,
title = "Impact of platelet volume on the clinical outcomes of patients with acute coronary syndrome",
abstract = "Background: Platelets with high hemostatic activity play an important role in the pathophysiology of acute coronary syndrome (ACS), and mean platelet volume (MPV) has been proposed to be an indicator of platelet reactivity. We evaluated the predictive value of MPV and the responsive value of MPV with different antiplatelet agents in association with the clinical outcomes of ACS patients. Methods: A total of 1094 patients with ACS and 472 patients without ACS were included. Blood samples were taken at hospital admission, at routine follow-up within one year, and beyond one year. The patients were divided into a “high MPV group” (> 9.0 fl, n = 305), “medium MPV group” (7.9-9.0 fl, n = 517), and “low MPV group” (< 7.9 fl, n = 272). The average follow-up time was 2.4 years, and the endpoints were major adverse cardiovascular events (MACEs) including all-cause mortality, time to recurrent ACS, target vessel re-intervention and stroke. Results: MPV was significantly higher in the patients with ACS than in those without ACS (8.6 ± 1.1 vs. 8.4 ± 1.0 fl, p = 0.007). MPV decreased in the following year (8.38 ± 1.02 fl, p < 0.001) and also beyond one year (8.38 ± 0.94 fl, p < 0.001) after ACS events. The changes in MPV were not significantly different between the patients receiving either clopidogrel or ticagrelor. The high MPV group had more cardiovascular risk factors and more MACEs than the low MPV group (p = 0.017). Conclusions: A higher MPV in patients with ACS was associated with more cardiovascular risk factors and more cardiovascular events during clinical follow-up.",
author = "Chang, {Hsien Yuan} and Hsu, {Ling Wei} and Lee, {Cheng Han} and Lin, {Chih Chan} and Huang, {Chen Wei} and Chen, {Po Wei} and Yang, {Po Kai} and Hsueh, {Yang Che} and Liu, {Ping Yen}",
year = "2019",
month = "1",
day = "1",
doi = "10.6515/ACS.201911_35(6).20190423B",
language = "English",
volume = "35",
pages = "563--570",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
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}

TY - JOUR

T1 - Impact of platelet volume on the clinical outcomes of patients with acute coronary syndrome

AU - Chang, Hsien Yuan

AU - Hsu, Ling Wei

AU - Lee, Cheng Han

AU - Lin, Chih Chan

AU - Huang, Chen Wei

AU - Chen, Po Wei

AU - Yang, Po Kai

AU - Hsueh, Yang Che

AU - Liu, Ping Yen

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Platelets with high hemostatic activity play an important role in the pathophysiology of acute coronary syndrome (ACS), and mean platelet volume (MPV) has been proposed to be an indicator of platelet reactivity. We evaluated the predictive value of MPV and the responsive value of MPV with different antiplatelet agents in association with the clinical outcomes of ACS patients. Methods: A total of 1094 patients with ACS and 472 patients without ACS were included. Blood samples were taken at hospital admission, at routine follow-up within one year, and beyond one year. The patients were divided into a “high MPV group” (> 9.0 fl, n = 305), “medium MPV group” (7.9-9.0 fl, n = 517), and “low MPV group” (< 7.9 fl, n = 272). The average follow-up time was 2.4 years, and the endpoints were major adverse cardiovascular events (MACEs) including all-cause mortality, time to recurrent ACS, target vessel re-intervention and stroke. Results: MPV was significantly higher in the patients with ACS than in those without ACS (8.6 ± 1.1 vs. 8.4 ± 1.0 fl, p = 0.007). MPV decreased in the following year (8.38 ± 1.02 fl, p < 0.001) and also beyond one year (8.38 ± 0.94 fl, p < 0.001) after ACS events. The changes in MPV were not significantly different between the patients receiving either clopidogrel or ticagrelor. The high MPV group had more cardiovascular risk factors and more MACEs than the low MPV group (p = 0.017). Conclusions: A higher MPV in patients with ACS was associated with more cardiovascular risk factors and more cardiovascular events during clinical follow-up.

AB - Background: Platelets with high hemostatic activity play an important role in the pathophysiology of acute coronary syndrome (ACS), and mean platelet volume (MPV) has been proposed to be an indicator of platelet reactivity. We evaluated the predictive value of MPV and the responsive value of MPV with different antiplatelet agents in association with the clinical outcomes of ACS patients. Methods: A total of 1094 patients with ACS and 472 patients without ACS were included. Blood samples were taken at hospital admission, at routine follow-up within one year, and beyond one year. The patients were divided into a “high MPV group” (> 9.0 fl, n = 305), “medium MPV group” (7.9-9.0 fl, n = 517), and “low MPV group” (< 7.9 fl, n = 272). The average follow-up time was 2.4 years, and the endpoints were major adverse cardiovascular events (MACEs) including all-cause mortality, time to recurrent ACS, target vessel re-intervention and stroke. Results: MPV was significantly higher in the patients with ACS than in those without ACS (8.6 ± 1.1 vs. 8.4 ± 1.0 fl, p = 0.007). MPV decreased in the following year (8.38 ± 1.02 fl, p < 0.001) and also beyond one year (8.38 ± 0.94 fl, p < 0.001) after ACS events. The changes in MPV were not significantly different between the patients receiving either clopidogrel or ticagrelor. The high MPV group had more cardiovascular risk factors and more MACEs than the low MPV group (p = 0.017). Conclusions: A higher MPV in patients with ACS was associated with more cardiovascular risk factors and more cardiovascular events during clinical follow-up.

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U2 - 10.6515/ACS.201911_35(6).20190423B

DO - 10.6515/ACS.201911_35(6).20190423B

M3 - Article

AN - SCOPUS:85075078156

VL - 35

SP - 563

EP - 570

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

SN - 1011-6842

IS - 6

ER -