Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia

Hui Chun Tsuang; Wei J. Chen; Sheng Hsiang Lin; Teng Yi Chen; Yi Lin Chang; Kuo Hao Huang; Hsien Yuan Lane

doi:10.1016/j.psychres.2012.09.038

Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia

Hui Chun Tsuang, Wei J. Chen, Sheng Hsiang Lin, Teng Yi Chen, Yi Lin Chang, Kuo Hao Huang, Hsien Yuan Lane

Institute of Clinical Medicine

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The impact of the serotonin_2a (5-HT2A) receptor gene on the pathophysiology of schizophrenia is inconclusive despite accumulating evidence implicating the 5-HT2A receptor. To simplify the complexity of genetic analysis, we used an endophenotype approach. The relationship between Continuous Performance Test (CPT) performance and 5-HT2A receptor gene variance was examined. Both patients with schizophrenia (n=255) and healthy volunteers (n=380) were recruited. All were genotyped for the -1438A/G polymorphism and assessed with the CPT. The Positive and Negative Syndrome Scale and the Scale for the Assessment of Negative Symptoms were used to evaluate patients' clinical symptoms. The distribution of the 5-HT2A genotypes between patients and healthy controls was similar. Impulse control in schizophrenic patients, assessed with the false-alarm rate of the CPT, differed significantly between those with different 5-HT2A genotypes. We hypothesize that the 5-HT2A receptor gene is a modifier gene of schizophrenia and suggest that additional studies are warranted.

Original language	English
Pages (from-to)	105-110
Number of pages	6
Journal	Psychiatry Research
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/j.psychres.2012.09.038
Publication status	Published - 2013 Jul 30

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2012.09.038

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title = "Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia",

abstract = "The impact of the serotonin2a (5-HT2A) receptor gene on the pathophysiology of schizophrenia is inconclusive despite accumulating evidence implicating the 5-HT2A receptor. To simplify the complexity of genetic analysis, we used an endophenotype approach. The relationship between Continuous Performance Test (CPT) performance and 5-HT2A receptor gene variance was examined. Both patients with schizophrenia (n=255) and healthy volunteers (n=380) were recruited. All were genotyped for the -1438A/G polymorphism and assessed with the CPT. The Positive and Negative Syndrome Scale and the Scale for the Assessment of Negative Symptoms were used to evaluate patients' clinical symptoms. The distribution of the 5-HT2A genotypes between patients and healthy controls was similar. Impulse control in schizophrenic patients, assessed with the false-alarm rate of the CPT, differed significantly between those with different 5-HT2A genotypes. We hypothesize that the 5-HT2A receptor gene is a modifier gene of schizophrenia and suggest that additional studies are warranted.",

author = "Tsuang, {Hui Chun} and Chen, {Wei J.} and Lin, {Sheng Hsiang} and Chen, {Teng Yi} and Chang, {Yi Lin} and Huang, {Kuo Hao} and Lane, {Hsien Yuan}",

note = "Funding Information: This study was funded by the National Science Council, Taiwan (NSC-98-2627-B-039-001, NSC-101-2325-B-039-009, and NSC-101-2314-B-039-030-MY3); National Health Research Institutes, Taiwan (NHRI-EX-101-9904NI); Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004); and China Medical University Hospital (DMR-99-115 and DMR-99-120). Besides, there is no conflict of interest that might influence authors' objectivity.",

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AU - Chang, Yi Lin

AU - Huang, Kuo Hao

AU - Lane, Hsien Yuan

N1 - Funding Information: This study was funded by the National Science Council, Taiwan (NSC-98-2627-B-039-001, NSC-101-2325-B-039-009, and NSC-101-2314-B-039-030-MY3); National Health Research Institutes, Taiwan (NHRI-EX-101-9904NI); Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH101-TD-B-111-004); and China Medical University Hospital (DMR-99-115 and DMR-99-120). Besides, there is no conflict of interest that might influence authors' objectivity.

PY - 2013/7/30

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N2 - The impact of the serotonin2a (5-HT2A) receptor gene on the pathophysiology of schizophrenia is inconclusive despite accumulating evidence implicating the 5-HT2A receptor. To simplify the complexity of genetic analysis, we used an endophenotype approach. The relationship between Continuous Performance Test (CPT) performance and 5-HT2A receptor gene variance was examined. Both patients with schizophrenia (n=255) and healthy volunteers (n=380) were recruited. All were genotyped for the -1438A/G polymorphism and assessed with the CPT. The Positive and Negative Syndrome Scale and the Scale for the Assessment of Negative Symptoms were used to evaluate patients' clinical symptoms. The distribution of the 5-HT2A genotypes between patients and healthy controls was similar. Impulse control in schizophrenic patients, assessed with the false-alarm rate of the CPT, differed significantly between those with different 5-HT2A genotypes. We hypothesize that the 5-HT2A receptor gene is a modifier gene of schizophrenia and suggest that additional studies are warranted.

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Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia

Abstract

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