Impedimetric monitoring of cell attachment on interdigitated microelectrodes

Bin Wha Chang, Che Hsiung Chen, Shin Jyh Ding, David Chan Hen Chen, Hsien Chang Chang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

An on-line and real-time impedimetric system was developed to monitor and quantify cell attachment on interdigitated microelectrodes. Changes in admittance at frequency lower than 10 kHz were positively correlated with the extent of cell attachment (102 to 107 cells/cm 2). As judged from the admittance change, the onset and the extent of cell attachment were facilitated when the electrodes were modified with RGD-C peptide, an artificial peptide with a high affinity toward cellulose surface. The system is useful in estimating seeding cell density and characterizing bio-compatible materials with suitable cell affinity.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume105
Issue number2
DOIs
Publication statusPublished - 2005 Mar 28

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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