Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers

Yi Ping Lai, Chung-Dann Kan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.

Original languageEnglish
Title of host publication2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationSmarter Technology for a Healthier World, EMBC 2017 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2068-2071
Number of pages4
ISBN (Electronic)9781509028092
DOIs
Publication statusPublished - 2017 Sep 13
Event39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017 - Jeju Island, Korea, Republic of
Duration: 2017 Jul 112017 Jul 15

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017
CountryKorea, Republic of
CityJeju Island
Period17-07-1117-07-15

Fingerprint

Stents
Collagen
Antibodies
Magnesium
Heparin
Anti-Idiotypic Antibodies
Blood
Drug-Eluting Stents
Endothelial cells
Fourier Transform Infrared Spectroscopy
Collagen Type I
Biocompatibility
Fluorescent Antibody Technique
Energy dispersive spectroscopy
Multilayers
Thrombosis
Staining and Labeling
Scanning electron microscopy
Endothelial Progenitor Cells

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Lai, Y. P., & Kan, C-D. (2017). Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings (pp. 2068-2071). [8037260] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2017.8037260
Lai, Yi Ping ; Kan, Chung-Dann. / Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. pp. 2068-2071 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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abstract = "Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.",
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Lai, YP & Kan, C-D 2017, Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers. in 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings., 8037260, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Institute of Electrical and Electronics Engineers Inc., pp. 2068-2071, 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2017, Jeju Island, Korea, Republic of, 17-07-11. https://doi.org/10.1109/EMBC.2017.8037260

Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers. / Lai, Yi Ping; Kan, Chung-Dann.

2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2017. p. 2068-2071 8037260 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.

AB - Instentrestenosis and late stent thrombosis continue to be the greatest limitations of drug-eluting stents. In this study, an anti-CD34 antibody functionalized multilayer of heparin/collagen type I is developed by layer-by-layer assemble to enhance biocompatibility and recruit endothelial progenitor cells. The SEM results demonstrate that (Hep/Col)5-coated samples have a rougher surface compared to (Hep/Col)2-coated samples and untreated samples. The EDX and FTIR results both confirmed the presence of heparin and collagen onto the modified samples. The immunofluorescence staining outcomes demonstrated that anti-CD34 antibody has successfully immobilized onto modified Mg discs.

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Lai YP, Kan C-D. Improve blood compatibility of bioresorbable magnesium stents coated with functionalized anti-CD34 antibody and heparin-collagen multiplayers. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2017. p. 2068-2071. 8037260. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2017.8037260