Improved therapeutic efficacy via magnetite nanoconjugates derived synchronization of hyperthermochemotherapy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A novel nanoconjugate enabled synchronization of localized hyperthermia and drug release was presented. The hyperthermia was induced by the radiofrequency (RF) at 1.3MHz to trigger the release of 5-fluouracil (5-FU) anti-cancer drugs from magnetite nanocrystals core by breaking their hydrogen bond with the polynucleotide polymer carrier. The anti-Human Epidermal Growth Factor Receptor 2 (anti-HER2) antibody was end-modified on the polyethylene glycol to achieve cancer cell specific targeting and biological stealth. The 22 nm-sized magnetites displayed high saturation magnetization (94 emu/g) comparable to bulk magnetite (92 emu/g). The local regional heat triggers synchronized drug release and physical thermal damage of the cancer cells and significantly improved the anti-cancer efficacy in both in vitro and in vivo models than hyperthermia or chemotherapy alone as evidenced by cell viability assays and pathological examines. Complete remission of the disease in vivo was achieved through radiofrequency synchronization of hyperthermia and chemotherapy after intravenous injection of the nanoconjugates.

Original languageEnglish
Title of host publication2012 12th IEEE International Conference on Nanotechnology, NANO 2012
DOIs
Publication statusPublished - 2012 Nov 22
Event2012 12th IEEE International Conference on Nanotechnology, NANO 2012 - Birmingham, United Kingdom
Duration: 2012 Aug 202012 Aug 23

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Other

Other2012 12th IEEE International Conference on Nanotechnology, NANO 2012
CountryUnited Kingdom
CityBirmingham
Period12-08-2012-08-23

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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  • Cite this

    Li, T. J., Huang, C-C., Shieh, D-B., & Yeh, C-S. (2012). Improved therapeutic efficacy via magnetite nanoconjugates derived synchronization of hyperthermochemotherapy. In 2012 12th IEEE International Conference on Nanotechnology, NANO 2012 [6322055] (Proceedings of the IEEE Conference on Nanotechnology). https://doi.org/10.1109/NANO.2012.6322055