TY - JOUR
T1 - Improvement of physical properties of poly(glycerol sebacate) by copolymerization with polyhydroxybutyrate-diols
AU - Tang, Bo Chen
AU - Yao, Chao Ling
AU - Xieh, Ku Yu
AU - Hong, Shinn Gwo
N1 - Publisher Copyright:
© 2017, Springer Science+Business Media B.V.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The characterizations and physical properties of elastomeric poly(glycerol sebacate) (PGS) copolymerized with different amounts of polyhydroxybutyrate diol (PHB-diol) were analyzed with 1H-NMR, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), mechanical test, biodegradation test, and cytotoxicity analysis. The chemical composition of the PHB-diol prepared and the copolymerization reaction of the PHB-diol in the PGS were confirmed by 1H-NMR. From 1H-NMR analysis, the PHB-diol prepared had the molecular weight about 989.6 g/mol and a faster crystallization rate than the PHB according to the DSC measurement. The tensile/compressive strengths of PGS-co-(PHB-diol) increased while the crosslinking densities decreased with the amount of PHB-diol copolymerized. The PGS-co-(PHB-diol) had a slower biodegradation rate but a worse thermal stability than the PGS. Additionally, the biodegradable PGS-co-(PHB-diol) elastomers prepared exhibited no cytotoxicity and could replace PGS used in bio-fields.
AB - The characterizations and physical properties of elastomeric poly(glycerol sebacate) (PGS) copolymerized with different amounts of polyhydroxybutyrate diol (PHB-diol) were analyzed with 1H-NMR, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), mechanical test, biodegradation test, and cytotoxicity analysis. The chemical composition of the PHB-diol prepared and the copolymerization reaction of the PHB-diol in the PGS were confirmed by 1H-NMR. From 1H-NMR analysis, the PHB-diol prepared had the molecular weight about 989.6 g/mol and a faster crystallization rate than the PHB according to the DSC measurement. The tensile/compressive strengths of PGS-co-(PHB-diol) increased while the crosslinking densities decreased with the amount of PHB-diol copolymerized. The PGS-co-(PHB-diol) had a slower biodegradation rate but a worse thermal stability than the PGS. Additionally, the biodegradable PGS-co-(PHB-diol) elastomers prepared exhibited no cytotoxicity and could replace PGS used in bio-fields.
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U2 - 10.1007/s10965-017-1371-8
DO - 10.1007/s10965-017-1371-8
M3 - Article
AN - SCOPUS:85034823381
SN - 1022-9760
VL - 24
JO - Journal of Polymer Research
JF - Journal of Polymer Research
IS - 12
M1 - 215
ER -