Improving in-hospital mortality in elderly patients after acute coronary syndrome-A nationwide analysis of 97,220 patients in Taiwan during 2004-2008

Tung Han Hsieh, Jung-Der Wang, Liang-Miin Tsai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Elderly patients seem to have especially poor outcomes after acquiring acute coronary syndrome (ACS).Weconducted this study to examine the in-hospitalmortality by utilization of invasive coronary therapies and age in a nationwide population in Taiwan. Methods: This observational studywas conducted on a retrospective cohort fromJanuary 2004 to December 2008. Epidemiological features, including incidence rate and clinical characteristics of ACS in a Chinese population were investigated. Risk factors of in-hospitalmortality, includingmyocardial infarction, shock, previous history of stroke, chronic kidney disease, diabetes mellitus, congestive heart failure, pneumonia, chronic obstructive pulmonary disease, dementia, peripheral arterial occlusive disease, septicemia and the use of invasive coronary procedures, were explored using a logistic regression model. Results: A total of 97,220 patients were enrolled, and 53.6% of them were elderly. A significant decrease in the utilization rate of invasive coronary therapies (diagnostic coronary angiography and PCI) and increased in-hospital mortality (pb0.001) were observed as patient age increased. Adjusted multivariate logistic regression analysis revealed that the impact of PCI in reducing in-hospital mortality is consistent across age groups, including those older than 75 years old. Conclusions: Our nationwide study provides evidence that PCI is associated with significant improvement of inhospital mortality in patients with ACS. Even the very elderly patients could benefit from PCI. However, currently the utilization rate of PCI in the aging population still does not present enough. A prospective study is indicated to corroborate the findings of this study.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalInternational Journal of Cardiology
Volume155
Issue number1
DOIs
Publication statusPublished - 2012 Feb 23

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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