In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve

Eric Chia, Chou Chin Lin, Chung Yi Sue, Ming Shaung Ju

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression- and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography (Doppler OCT) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic model (QLV) to determine the viscoelasticity of the nerves. The results show that the nerves in the diabetic group had a longer relaxation time than those in the normal group. Consequently, the Doppler OCT observations reveal that in contrast to the normal arterioles, the diabetic arterioles did not dilate in the relaxation phase. The results of the force data integrated with the corresponding arteriole dilatation images may explain why the diabetic patients are more prone to carpal tunnel syndrome. The results may facilitate developing new approaches for treating diabetic neuropathy and for nerve repair and regeneration.

Original languageEnglish
Title of host publication1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
EditorsShyh-Hau Wang, Fong-Chin Su, Ming-Long Yeh
PublisherSpringer Verlag
Pages42-45
Number of pages4
ISBN (Electronic)9783319122618
DOIs
Publication statusPublished - 2015 Jan 1
Event1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
Duration: 2014 Oct 92014 Oct 12

Publication series

NameIFMBE Proceedings
Volume47
ISSN (Print)1680-0737

Other

Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
CountryTaiwan
CityTainan
Period14-10-0914-10-12

Fingerprint

Optical tomography
Rats
Medical problems
Viscoelasticity
Blood vessels
Relaxation time
Tunnels
Repair
Tissue
Mechanical properties

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Chia, E., Lin, C. C., Sue, C. Y., & Ju, M. S. (2015). In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve. In S-H. Wang, F-C. Su, & M-L. Yeh (Eds.), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering (pp. 42-45). (IFMBE Proceedings; Vol. 47). Springer Verlag. https://doi.org/10.1007/978-3-319-11128-5_13
Chia, Eric ; Lin, Chou Chin ; Sue, Chung Yi ; Ju, Ming Shaung. / In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve. 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. editor / Shyh-Hau Wang ; Fong-Chin Su ; Ming-Long Yeh. Springer Verlag, 2015. pp. 42-45 (IFMBE Proceedings).
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abstract = "Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression- and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography (Doppler OCT) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic model (QLV) to determine the viscoelasticity of the nerves. The results show that the nerves in the diabetic group had a longer relaxation time than those in the normal group. Consequently, the Doppler OCT observations reveal that in contrast to the normal arterioles, the diabetic arterioles did not dilate in the relaxation phase. The results of the force data integrated with the corresponding arteriole dilatation images may explain why the diabetic patients are more prone to carpal tunnel syndrome. The results may facilitate developing new approaches for treating diabetic neuropathy and for nerve repair and regeneration.",
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Chia, E, Lin, CC, Sue, CY & Ju, MS 2015, In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve. in S-H Wang, F-C Su & M-L Yeh (eds), 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol. 47, Springer Verlag, pp. 42-45, 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014, Tainan, Taiwan, 14-10-09. https://doi.org/10.1007/978-3-319-11128-5_13

In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve. / Chia, Eric; Lin, Chou Chin; Sue, Chung Yi; Ju, Ming Shaung.

1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. ed. / Shyh-Hau Wang; Fong-Chin Su; Ming-Long Yeh. Springer Verlag, 2015. p. 42-45 (IFMBE Proceedings; Vol. 47).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression- and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography (Doppler OCT) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic model (QLV) to determine the viscoelasticity of the nerves. The results show that the nerves in the diabetic group had a longer relaxation time than those in the normal group. Consequently, the Doppler OCT observations reveal that in contrast to the normal arterioles, the diabetic arterioles did not dilate in the relaxation phase. The results of the force data integrated with the corresponding arteriole dilatation images may explain why the diabetic patients are more prone to carpal tunnel syndrome. The results may facilitate developing new approaches for treating diabetic neuropathy and for nerve repair and regeneration.

AB - Diabetes mellitus is one of the most common diseases in the world and can causemany types of neuropathies, and even mortality. It is therefore important to understand how diabetes mellitus alters the mechanical properties of nerve tissues and their blood vessels. In this study, in situ compression- and-hold circular compression tests were applied to the sciatic nerves of both diabetic rats and normal rats. Doppler optical coherence tomography (Doppler OCT) was then utilized to monitor the configuration of the arterioles in two groups of rats. The force data acquired in the compression tests were fitted by using Fung’s quasi-linear viscoelastic model (QLV) to determine the viscoelasticity of the nerves. The results show that the nerves in the diabetic group had a longer relaxation time than those in the normal group. Consequently, the Doppler OCT observations reveal that in contrast to the normal arterioles, the diabetic arterioles did not dilate in the relaxation phase. The results of the force data integrated with the corresponding arteriole dilatation images may explain why the diabetic patients are more prone to carpal tunnel syndrome. The results may facilitate developing new approaches for treating diabetic neuropathy and for nerve repair and regeneration.

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Chia E, Lin CC, Sue CY, Ju MS. In situ circular compression and doppler optical coherence tomography studies on effects of diabetic mellitus on vesa nervonum of sciatic nerve. In Wang S-H, Su F-C, Yeh M-L, editors, 1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering. Springer Verlag. 2015. p. 42-45. (IFMBE Proceedings). https://doi.org/10.1007/978-3-319-11128-5_13