TY - JOUR
T1 - In situ tailoring of carbon dots-metal ferrite nanohybrid as multipurpose marker agent of HeLa cancer cells
AU - Sugito, Siti Febtria Asrini
AU - Firdaus, Fakhri
AU - Aung, Yu
AU - Sakti, Satya Candra Wibawa
AU - Chiu, Hsien Tai
AU - Fahmi, Mochamad Zakki
N1 - Funding Information:
The authors thank to Universitas Airlangga for SATU joint research scheme (under Contract 1312/UN3.15/PT/2021), and Indonesian Scholar Education Program of Ministry of Education, Culture and Higher Education-LPDP.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to The Materials Research Society.
PY - 2022/6/14
Y1 - 2022/6/14
N2 - The development of multifunction material was considered to attain effectiveness on cancer treatment. The present study pursues the potential application of metal ferrite nanoparticles covered with CDs to get dual-active nanomaterial on fluorescent and magnetic responses that were prepared on a one-pot solvothermal method. Some analyses indicated the nanohybrids consisted of amorphous structure. Besides, the optical analysis performed optimum emission with QY percentage up to 0.9 and 0.6, respectively. Magnetic response assessment confirmed CDs@MnFe2O4-15 has good superparamagnetic properties with saturation magnetization value of 38.485 emu/g, while CDs@CuFe2O4-15 at 9.5245 emu/g. The DLS measurement showed an average size of CDs@MnFe2O4-45 at 63.98 nm, while CDs@CuFe2O4-45 at 55.46 nm. Then, this nanosized drive to perform good photoluminescent properties and good cytotoxicity due to the nanohybrids of CDs@MFe2O4-45 can easily enter the HeLa cells without harming its original structure. The above finding has well-proven good clinical potency of the nanohybrid as simultaneous fluorescent and magnetic-based detection. Graphical abstract: [Figure not available: see fulltext.]
AB - The development of multifunction material was considered to attain effectiveness on cancer treatment. The present study pursues the potential application of metal ferrite nanoparticles covered with CDs to get dual-active nanomaterial on fluorescent and magnetic responses that were prepared on a one-pot solvothermal method. Some analyses indicated the nanohybrids consisted of amorphous structure. Besides, the optical analysis performed optimum emission with QY percentage up to 0.9 and 0.6, respectively. Magnetic response assessment confirmed CDs@MnFe2O4-15 has good superparamagnetic properties with saturation magnetization value of 38.485 emu/g, while CDs@CuFe2O4-15 at 9.5245 emu/g. The DLS measurement showed an average size of CDs@MnFe2O4-45 at 63.98 nm, while CDs@CuFe2O4-45 at 55.46 nm. Then, this nanosized drive to perform good photoluminescent properties and good cytotoxicity due to the nanohybrids of CDs@MFe2O4-45 can easily enter the HeLa cells without harming its original structure. The above finding has well-proven good clinical potency of the nanohybrid as simultaneous fluorescent and magnetic-based detection. Graphical abstract: [Figure not available: see fulltext.]
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U2 - 10.1557/s43578-022-00612-3
DO - 10.1557/s43578-022-00612-3
M3 - Article
AN - SCOPUS:85131313730
SN - 0884-2914
VL - 37
SP - 1941
EP - 1951
JO - Journal of Materials Research
JF - Journal of Materials Research
IS - 11
ER -