In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

W. C. Ko; H. C. Lee; Y. C. Chuang; S. H. Ten; C. Y. Su; J. J. Wu

doi:10.1128/AAC.45.4.1281-1283.2001

In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

W. C. Ko, H. C. Lee, Y. C. Chuang, S. H. Ten, C. Y. Su, J. J. Wu

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

Original language	English
Pages (from-to)	1281-1283
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	4
DOIs	https://doi.org/10.1128/AAC.45.4.1281-1283.2001
Publication status	Published - 2001

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AU - Ko, W. C.

AU - Lee, H. C.

AU - Chuang, Y. C.

AU - Ten, S. H.

AU - Su, C. Y.

AU - Wu, J. J.

PY - 2001

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AB - The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

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