In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila

W. C. Ko, H. C. Lee, Y. C. Chuang, S. H. Ten, C. Y. Su, J. J. Wu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.

Original languageEnglish
Pages (from-to)1281-1283
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume45
Issue number4
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila'. Together they form a unique fingerprint.

Cite this