Abstract
The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to β-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37°C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.
| Original language | English |
|---|---|
| Pages (from-to) | 643-650 |
| Number of pages | 8 |
| Journal | Journal of Biomedical Materials Research - Part B Applied Biomaterials |
| Volume | 91 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Biomaterials
- Biomedical Engineering
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In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy. / Lee, Jing-Wei; Lin, Dan Jae; Ju, Chien-Ping; Yin, Hsiang Shu; Chuang, Cheng Chung; Chern, Jiin-Huey.
In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 91, No. 2, 01.11.2009, p. 643-650.Research output: Contribution to journal › Article
TY - JOUR
T1 - In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy
AU - Lee, Jing-Wei
AU - Lin, Dan Jae
AU - Ju, Chien-Ping
AU - Yin, Hsiang Shu
AU - Chuang, Cheng Chung
AU - Chern, Jiin-Huey
PY - 2009/11/1
Y1 - 2009/11/1
N2 - The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to β-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37°C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.
AB - The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to β-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37°C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.
UR - http://www.scopus.com/inward/record.url?scp=71649115164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71649115164&partnerID=8YFLogxK
U2 - 10.1002/jbm.b.31440
DO - 10.1002/jbm.b.31440
M3 - Article
C2 - 19630058
AN - SCOPUS:71649115164
VL - 91
SP - 643
EP - 650
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
SN - 1552-4973
IS - 2
ER -