In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy

Jing Wei Lee, Dan Jae Lin, Chien Ping Ju, Hsiang Shu Yin, Cheng Chung Chuang, Jiin Huey Chern Lin

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13 Citations (Scopus)


The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to β-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37°C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.

Original languageEnglish
Pages (from-to)643-650
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number2
Publication statusPublished - 2009 Nov

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


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