In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy

Jing-Wei Lee, Dan Jae Lin, Chien-Ping Ju, Hsiang Shu Yin, Cheng Chung Chuang, Jiin-Huey Chern

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The newly developed Ti-15Mo-1Bi alloy not only possesses all the desirable mechanical properties inherent to β-Ti Mo alloys, but may even enjoy better clinical applicability with the addition of bismuth element, which has long been administered as antibacterial and antitumor medicines. A significantly higher viability of 3T3 cells was demonstrated when they were grown on Ti-15Mo-1Bi alloy than on Ti-15Mo and Ti-6Al-4V. Cells incubated in the medium conditioned by Bi powder at 37°C for 96 h exhibited viability similar to that in the blank group and higher than that in the Ni conditioned group. In vivo experiments using 6 mm x 2 mm metal pin implanted into the epicondyle of rabbit femur revealed superior potential of new bone growth and better persistence of the deposited bony tissue with the Ti-15Mo-1Bi alloy in contrast to that with Ti-6Al-4V. The difference is evident at 12th week and become even more prominent after 26 weeks, with the new bone area measuring 249% of that around Ti-6Al-4V alloy. In summary, Ti-15Mo-1Bi alloys show no cytotoxicity in the in-vitro test and demonstrates superior ability to retain bone in the in-vivo implantation experiment as compared with Ti-6Al-4V alloys.

Original languageEnglish
Pages (from-to)643-650
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume91
Issue number2
DOIs
Publication statusPublished - 2009 Nov 1

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Bone
Bismuth
Cytotoxicity
Conditioned Culture Medium
Powders
Medicine
Metals
Experiments
Tissue
Mechanical properties
Ti-15Mo-1Bi alloy
titanium alloy (TiAl6V4)

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Lee, Jing-Wei ; Lin, Dan Jae ; Ju, Chien-Ping ; Yin, Hsiang Shu ; Chuang, Cheng Chung ; Chern, Jiin-Huey. / In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy. In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2009 ; Vol. 91, No. 2. pp. 643-650.
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In-vitro and in-vivo evaluation of a new Ti-15Mo-1Bi alloy. / Lee, Jing-Wei; Lin, Dan Jae; Ju, Chien-Ping; Yin, Hsiang Shu; Chuang, Cheng Chung; Chern, Jiin-Huey.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 91, No. 2, 01.11.2009, p. 643-650.

Research output: Contribution to journalArticle

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