In vivo and in vitro anti-tumor effects of fungal extracts

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8%, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54%, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine.

Original languageEnglish
Pages (from-to)2546-2556
Number of pages11
JournalMolecules
Volume19
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

Fingerprint

Tumors
tumors
Coriolaceae
cancer
Ethanol
ethyl alcohol
Neoplasms
Fungi
fungi
apoptosis
Bearings (structural)
Cells
Apoptosis
Water
Bioelectric potentials
Bromides
supplements
Medicine
In Vitro Techniques
cells

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

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title = "In vivo and in vitro anti-tumor effects of fungal extracts",
abstract = "Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines. The water or ethanol extracts of Fomitopsis pinicola (F. pinicola), Ganoderma sinense, Fomitopsis officinalis, Polyporus melanopus, and Taiwanofungus camphorates were used to evaluate the anti-cancer activities in various cancer cells. We found that all of the fungi ethanol extracts used in this study exert anti-cancer activities in vitro, whereas water extracts show lower inhibitory activities as determined by 3-(4,5-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Among the tested fungi species, F. pinicola ethanol extract exerts the most significant anti-cancer activity (growth inhibitory ratio 82.8{\%}, p < 0.001) by increasing cell apoptosis. Moreover, F. pinicola ethanol extract significantly decreased tumor size (tumor growth inhibitory ratio 54{\%}, p < 0.05) and increased the lifespan in mice bearing sarcoma-180 tumors. Taken together, this is the first study indicating the anti-tumor effect of F. pinicola in vivo and in vitro. F. pinicola ethanol extract induces cell apoptosis to exert a significant anti-tumor activity, with potential to be a new alternative anti-tumor medicine.",
author = "Wu, {Hung Tsung} and Lu, {Feng Hwa} and Su, {Yu Chu} and Ou, {Horng Yih} and Hung, {Hao Chang} and Wu, {Jin Shang} and Yang, {Yi Ching} and Chang, {Chih Jen}",
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In vivo and in vitro anti-tumor effects of fungal extracts. / Wu, Hung Tsung; Lu, Feng Hwa; Su, Yu Chu; Ou, Horng Yih; Hung, Hao Chang; Wu, Jin Shang; Yang, Yi Ching; Chang, Chih Jen.

In: Molecules, Vol. 19, No. 2, 01.02.2014, p. 2546-2556.

Research output: Contribution to journalArticle

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AU - Wu, Hung Tsung

AU - Lu, Feng Hwa

AU - Su, Yu Chu

AU - Ou, Horng Yih

AU - Hung, Hao Chang

AU - Wu, Jin Shang

AU - Yang, Yi Ching

AU - Chang, Chih Jen

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