In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Chih Chao Hsu; Yuan Li Huang; Shaw Jeng Tsai; Chia Chin Sheu; Bu Miin Huang

doi:10.1016/S0024-3205(03)00595-2

In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Chih Chao Hsu, Yuan Li Huang, Shaw Jeng Tsai, Chia Chin Sheu, Bu Miin Huang

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Abstract

The in vivo and in vitro effects of Cordyceps sinensis (CS) and its extracted fractions on the secretion of testosterone in mice were studied. CS, F2 (water soluble protein), and F3 (poorly water soluble polysaccharide and protein) significantly stimulated in vitro testosterone production in purified mouse Leydig cells. However, F1 (water soluble polysaccharide) had no effect (p>0.05). F2 and F3 stimulated in vitro testosterone production in dose- and time-dependent relationships with maximal responses at 3 mg/ml for 3 h (p<0.05). An in vivo study illustrated that testosterone levels in plasma were significantly increased by CS, F2, and F3, respectively (p<0.05). Because CS, F2, and F3 stimulated both in vitro and in vivo testosterone secretions in mice, it is possible that CS might contribute to an alternative medicine for the treatment of some reproductive problems caused by insufficient testosterone levels in human males.

Original language	English
Pages (from-to)	2127-2136
Number of pages	10
Journal	Life Sciences
Volume	73
Issue number	16
DOIs	https://doi.org/10.1016/S0024-3205(03)00595-2
Publication status	Published - 2003 Sept 5

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General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry,Genetics and Molecular Biology

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10.1016/S0024-3205(03)00595-2

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title = "In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells",

abstract = "The in vivo and in vitro effects of Cordyceps sinensis (CS) and its extracted fractions on the secretion of testosterone in mice were studied. CS, F2 (water soluble protein), and F3 (poorly water soluble polysaccharide and protein) significantly stimulated in vitro testosterone production in purified mouse Leydig cells. However, F1 (water soluble polysaccharide) had no effect (p>0.05). F2 and F3 stimulated in vitro testosterone production in dose- and time-dependent relationships with maximal responses at 3 mg/ml for 3 h (p<0.05). An in vivo study illustrated that testosterone levels in plasma were significantly increased by CS, F2, and F3, respectively (p<0.05). Because CS, F2, and F3 stimulated both in vitro and in vivo testosterone secretions in mice, it is possible that CS might contribute to an alternative medicine for the treatment of some reproductive problems caused by insufficient testosterone levels in human males.",

author = "Hsu, {Chih Chao} and Huang, {Yuan Li} and Tsai, {Shaw Jeng} and Sheu, {Chia Chin} and Huang, {Bu Miin}",

note = "Funding Information: This study was supported by the National Science Council Grants NSC91-2320-B-006-070 and the Department of Health Grant DOH92-TD-1005 to BMH, Taiwan, Republic of China.",

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AU - Hsu, Chih Chao

AU - Huang, Yuan Li

AU - Tsai, Shaw Jeng

AU - Sheu, Chia Chin

AU - Huang, Bu Miin

N1 - Funding Information: This study was supported by the National Science Council Grants NSC91-2320-B-006-070 and the Department of Health Grant DOH92-TD-1005 to BMH, Taiwan, Republic of China.

PY - 2003/9/5

Y1 - 2003/9/5

N2 - The in vivo and in vitro effects of Cordyceps sinensis (CS) and its extracted fractions on the secretion of testosterone in mice were studied. CS, F2 (water soluble protein), and F3 (poorly water soluble polysaccharide and protein) significantly stimulated in vitro testosterone production in purified mouse Leydig cells. However, F1 (water soluble polysaccharide) had no effect (p>0.05). F2 and F3 stimulated in vitro testosterone production in dose- and time-dependent relationships with maximal responses at 3 mg/ml for 3 h (p<0.05). An in vivo study illustrated that testosterone levels in plasma were significantly increased by CS, F2, and F3, respectively (p<0.05). Because CS, F2, and F3 stimulated both in vitro and in vivo testosterone secretions in mice, it is possible that CS might contribute to an alternative medicine for the treatment of some reproductive problems caused by insufficient testosterone levels in human males.

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In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Abstract

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