In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells

Chih Chao Hsu, Yuan Li Huang, Shaw Jeng Tsai, Chia Chin Sheu, Bu Miin Huang

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

The in vivo and in vitro effects of Cordyceps sinensis (CS) and its extracted fractions on the secretion of testosterone in mice were studied. CS, F2 (water soluble protein), and F3 (poorly water soluble polysaccharide and protein) significantly stimulated in vitro testosterone production in purified mouse Leydig cells. However, F1 (water soluble polysaccharide) had no effect (p>0.05). F2 and F3 stimulated in vitro testosterone production in dose- and time-dependent relationships with maximal responses at 3 mg/ml for 3 h (p<0.05). An in vivo study illustrated that testosterone levels in plasma were significantly increased by CS, F2, and F3, respectively (p<0.05). Because CS, F2, and F3 stimulated both in vitro and in vivo testosterone secretions in mice, it is possible that CS might contribute to an alternative medicine for the treatment of some reproductive problems caused by insufficient testosterone levels in human males.

Original languageEnglish
Pages (from-to)2127-2136
Number of pages10
JournalLife Sciences
Volume73
Issue number16
DOIs
Publication statusPublished - 2003 Sep 5

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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