In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy

Tsung Ju Li, Chih Chia Huang, Pin Wei Ruan, Kuei Yi Chuang, Kuang Jing Huang, Dar Bin Shieh, Chen Sheng Yeh

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)

Abstract

We present an approach for synchronizing hyperthermia and thermal-responsive local drug release. The targeting probe has a magnetite nanocrystal (Fe34@PSMA) core and a polynucleotide shell that carries 5-fluorouracil (5-FU) and anti-human epidermal growth factor receptor 2 (anti-HER2) antibody for cancer cell-specific targeting. The targeting nanocrystals play as an important role to relay the externally delivered radiofrequency energy for tumor hyperthermia. Locoregional heat then triggers a drug release from the oligonucleotide carrier as it directly damages tumor cells. Cell viability assays and pathological examinations show that this synchronization is significantly more efficacious in both invitro and invivo models than hyperthermia or chemotherapy alone. Prominent tumor remission invivo was achieved through radiofrequency synchronization of hyperthermia and chemotherapy after the nanoparticle had been intravenously injected.

Original languageEnglish
Pages (from-to)7873-7883
Number of pages11
JournalBiomaterials
Volume34
Issue number32
DOIs
Publication statusPublished - 2013 Oct

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Ceramics and Composites
  • Biomaterials
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'In vivo anti-cancer efficacy of magnetite nanocrystal - based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy'. Together they form a unique fingerprint.

Cite this