In vivo exposure to carbon disulfide increases the contraction frequency of pregnant rat uteri through an indirect pathway

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Exposure to CS2, an organic solvent, is associated with an increased rate of abnormal labor or dysmenorrhea. Contraction of quiescent uteri during pregnancy can cause pre-term labor. We wish to know the effects of in vivo and in vitro exposures to CS2 on uterine contractions of mid-gestation rats. After 10-d exposure to 300 or 600 mg/kg CS2, uteri of pregnant rats were measured for contractile responses to various stimuli, such as KCl, oxytocin, carbachol or A23187, a calcium ionophore, using standard muscle bath apparatus. CS2 treatment significantly increased the contractile response to KCl, carbachol, and A23187. The increase to A23187 was the greatest. In contrast, in vitro exposure to CS2 immediately suppressed carbachol-induced contraction but did not affect spontaneous and KCl-induced contractions. Results showed the pregnant uterus of the rat is susceptible to CS2. The influence of in vivo exposure to CS2 on uterine contraction was opposite to that in vitro. The increased response of CS2-treated uteri to A23187 suggests that in vivo exposure to CS2 may sensitize contraction machinery to calcium through indirect pathways.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalLife Sciences
Volume66
Issue number3
DOIs
Publication statusPublished - 1999 Dec 10

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Carbon Disulfide
Calcimycin
Uterus
Rats
Carbachol
Uterine Contraction
Pregnancy
Dysmenorrhea
Calcium Ionophores
Oxytocin
Baths
Personnel
Calcium
Muscles
Organic solvents
Machinery
Muscle
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "In vivo exposure to carbon disulfide increases the contraction frequency of pregnant rat uteri through an indirect pathway",
abstract = "Exposure to CS2, an organic solvent, is associated with an increased rate of abnormal labor or dysmenorrhea. Contraction of quiescent uteri during pregnancy can cause pre-term labor. We wish to know the effects of in vivo and in vitro exposures to CS2 on uterine contractions of mid-gestation rats. After 10-d exposure to 300 or 600 mg/kg CS2, uteri of pregnant rats were measured for contractile responses to various stimuli, such as KCl, oxytocin, carbachol or A23187, a calcium ionophore, using standard muscle bath apparatus. CS2 treatment significantly increased the contractile response to KCl, carbachol, and A23187. The increase to A23187 was the greatest. In contrast, in vitro exposure to CS2 immediately suppressed carbachol-induced contraction but did not affect spontaneous and KCl-induced contractions. Results showed the pregnant uterus of the rat is susceptible to CS2. The influence of in vivo exposure to CS2 on uterine contraction was opposite to that in vitro. The increased response of CS2-treated uteri to A23187 suggests that in vivo exposure to CS2 may sensitize contraction machinery to calcium through indirect pathways.",
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In vivo exposure to carbon disulfide increases the contraction frequency of pregnant rat uteri through an indirect pathway. / Tsai, Mei-Ling; Chang, Jui Hsien; Huang, Bu-Miin; Liu, Ming-Yi.

In: Life Sciences, Vol. 66, No. 3, 10.12.1999, p. 201-208.

Research output: Contribution to journalArticle

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