In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods

Pai Chi Li, Churng Ren Chris Wang, Dar Bin Shieh, Chen Wei Wei, Chao Kang Liao, Carolina Poe, Suwen Jhan, Ann Ann Ding, Ya Na Wu

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated.

Original languageEnglish
Pages (from-to)18605-18615
Number of pages11
JournalOptics Express
Volume16
Issue number23
DOIs
Publication statusPublished - 2008 Nov 10

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

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    Li, P. C., Wang, C. R. C., Shieh, D. B., Wei, C. W., Liao, C. K., Poe, C., Jhan, S., Ding, A. A., & Wu, Y. N. (2008). In vivo photoacoustic molecular imaging with simultaneous multiple selective targeting using antibody-conjugated gold nanorods. Optics Express, 16(23), 18605-18615. https://doi.org/10.1364/OE.16.018605