Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: A positron emission tomography study with 4-[18F]-ADAM

Yi Wei Yeh, Pei Shen Ho, Chun Yen Chen, Shin Chang Kuo, Chih Sung Liang, Kuo Hsing Ma, Chyng Yann Shiue, Wen Sheng Huang, Cheng Yi Cheng, Tzu Yun Wang, Ru Band Lu, San Yuan Huang

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21 Citations (Scopus)

Abstract

Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In this study, we recruited 17 antidepressant-naive patients with MDD and 17 age- And gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2- Amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]- ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9). Results: A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni- Adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni- Adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni- Adjusted p-value < 0.01). Conclusions: This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non- Attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.

Original languageEnglish
Article number065
JournalInternational Journal of Neuropsychopharmacology
Volume18
Issue number3
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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