Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder: A positron emission tomography study with 4-[18F]-ADAM

Yi Wei Yeh, Pei Shen Ho, Chun Yen Chen, Shin Chang Kuo, Chih Sung Liang, Kuo Hsing Ma, Chyng Yann Shiue, Wen Sheng Huang, Cheng Yi Cheng, Tzu Yun Wang, Ru Band Lu, San Yuan Huang

Research output: Contribution to journalArticle

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Abstract

Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In this study, we recruited 17 antidepressant-naive patients with MDD and 17 age- And gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2- Amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]- ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9). Results: A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni- Adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni- Adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni- Adjusted p-value < 0.01). Conclusions: This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non- Attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.

Original languageEnglish
Article number065
JournalInternational Journal of Neuropsychopharmacology
Volume18
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Serotonin Plasma Membrane Transport Proteins
Major Depressive Disorder
Positron-Emission Tomography
Suicide
Mesencephalon
Depression
Prefrontal Cortex
Control Groups
Attempted Suicide
Thalamus
Antidepressive Agents
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Yeh, Yi Wei ; Ho, Pei Shen ; Chen, Chun Yen ; Kuo, Shin Chang ; Liang, Chih Sung ; Ma, Kuo Hsing ; Shiue, Chyng Yann ; Huang, Wen Sheng ; Cheng, Cheng Yi ; Wang, Tzu Yun ; Lu, Ru Band ; Huang, San Yuan. / Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder : A positron emission tomography study with 4-[18F]-ADAM. In: International Journal of Neuropsychopharmacology. 2015 ; Vol. 18, No. 3.
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abstract = "Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In this study, we recruited 17 antidepressant-naive patients with MDD and 17 age- And gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2- Amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]- ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9). Results: A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni- Adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni- Adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni- Adjusted p-value < 0.01). Conclusions: This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non- Attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.",
author = "Yeh, {Yi Wei} and Ho, {Pei Shen} and Chen, {Chun Yen} and Kuo, {Shin Chang} and Liang, {Chih Sung} and Ma, {Kuo Hsing} and Shiue, {Chyng Yann} and Huang, {Wen Sheng} and Cheng, {Cheng Yi} and Wang, {Tzu Yun} and Lu, {Ru Band} and Huang, {San Yuan}",
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Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder : A positron emission tomography study with 4-[18F]-ADAM. / Yeh, Yi Wei; Ho, Pei Shen; Chen, Chun Yen; Kuo, Shin Chang; Liang, Chih Sung; Ma, Kuo Hsing; Shiue, Chyng Yann; Huang, Wen Sheng; Cheng, Cheng Yi; Wang, Tzu Yun; Lu, Ru Band; Huang, San Yuan.

In: International Journal of Neuropsychopharmacology, Vol. 18, No. 3, 065, 01.01.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incongruent reduction of serotonin transporter associated with suicide attempts in patients with major depressive disorder

T2 - A positron emission tomography study with 4-[18F]-ADAM

AU - Yeh, Yi Wei

AU - Ho, Pei Shen

AU - Chen, Chun Yen

AU - Kuo, Shin Chang

AU - Liang, Chih Sung

AU - Ma, Kuo Hsing

AU - Shiue, Chyng Yann

AU - Huang, Wen Sheng

AU - Cheng, Cheng Yi

AU - Wang, Tzu Yun

AU - Lu, Ru Band

AU - Huang, San Yuan

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In this study, we recruited 17 antidepressant-naive patients with MDD and 17 age- And gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2- Amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]- ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9). Results: A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni- Adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni- Adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni- Adjusted p-value < 0.01). Conclusions: This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non- Attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.

AB - Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In this study, we recruited 17 antidepressant-naive patients with MDD and 17 age- And gender-matched healthy controls. SERT availability was measured in vivo with N,N-dimethyl-2-(2- Amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]- ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) and Beck Scale for Suicide Ideation were used to assess the severity of depression and the intent of suicide ideation prior to PET imaging. All subjects with MDD were in a current state of depression with HDRS scores ≧18. Subjects who attempted suicide within two weeks of the study onset were recruited in the depressed suicidal group (n = 8). Subjects with MDD who denied any prior suicide attempt were recruited into the depressed non-suicidal group (n = 9). Results: A significant reduction of SERT availability in the midbrain, thalamus, and striatum was noted in the MDD group relative to the control group (Bonferroni- Adjusted p-value < 0.05). Moreover, this effect was more pronounced in the depressed suicidal group compared to the control group (Bonferroni- Adjusted p-value < 0.01). Relative to both the depressed non-suicidal and control groups, the depressed suicidal group showed an increased prefrontal cortex (PFC)/midbrain SERT binding ratio (Bonferroni- Adjusted p-value < 0.01). Conclusions: This study suggests an incongruent reduction of PFC SERT binding relative to the midbrain might discriminate between depressed suicide attempters and non- Attempters in patients with MDD and may be involved in the pathophysiology of suicide behaviors.

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