Increased circulating CCR3+ type 2 helper T cells in house dust mite-sensitive Chinese patients with allergic diseases

Chrong-Reen Wang, Pei Chih Chen, Ming-Fei Liu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chemokine receptor expression has been shown to be associated with the differentiation of T helper cells. The CCR3, CXCR4 and CCR5 expression on circulating T cells were studied in 30 house dust mite sensitive-patients with allergic diseases and in another 30 healthy controls. The expression was analyzed in CD4, CD8 and double negative (DN) T cells by triple fluorescence staining. In addition, intracellular cytokine staining was performed in the CCR3+ CD4+ T cells. Increased circulating portions of CCR3+ CD4+ T cells and CCR3+ DN T cells were found in these patients (p < 0.01). There was no statistically significant difference in the expression of CXCR4 and CCR5 on T cells. The follow-up data of the patients did not show a statistically significant change in the CCR3 expression. IL-4 was expressed within CCR3+CD4+T cells upon activation. The IL-4 secreting CCR3+ type 2 T helper cells may play a pathogenetic role in immune responses of house dust mite-sensitive Chinese patients with allergic diseases.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalAsian Pacific Journal of Allergy and Immunology
Volume21
Issue number4
Publication statusPublished - 2003 Dec 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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