TY - JOUR
T1 - Increased Dose and Duration of Statin Use Is Associated with Decreased Asthma-Related Emergency Department Visits and Hospitalizations
AU - Wang, Jiu Yao
AU - Yao, Tsung Chieh
AU - Tsai, Yu Ting
AU - Wu, Ann Chen
AU - Tsai, Hui Ju
N1 - Funding Information:
Y-TT and T-CY are supported in part by grants from the Ministry of Science and Technology and National Health Research Institutes (PI: Tsai, NSC 101-2314-B-400-009-MY2, MOST 103-2314-B-400-004-MY3, PH-104-PP-14, PH-104-SP-05, PH-104-SP-16, PH-105-SP-05, and PH-105-SP-04; PI: Yao, NSC 101-2314-B-182A-044, NSC 102-2314-B-182A-048, MOST 103-2314-B-182-030, MOST 104-2314-B-182-046-MY2, and MOST 106-2314-B-182-051-MY3). This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by the National Health Research Institutes (Registered numbers: 99081, 99136, 99287, 101014, NHRID-101-548). The interpretation and conclusions contained herein do not represent those of the Bureau of National Health Insurance, Department of Health or National Health Research Institutes.
Publisher Copyright:
© 2018 American Academy of Allergy, Asthma & Immunology
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: Statins have pleiotropic anti-inflammatory and immunomodulatory effects, yet the effect of statin use on asthma-related emergency department (ED) visits and hospitalizations has remained unclear, especially in Asian populations. Objective: We sought to examine the effect of statin therapy on asthma-related ED visits and/or hospitalizations. Methods: A cohort study was conducted using data from Taiwan's National Health Insurance Research Database from 2001 to 2013. A total of 117,595 adult patients with asthma were included. The outcomes were defined as asthma-related ED visits and/or hospitalizations. Multiple Cox proportional hazards models were applied to determine the effect of statin use on asthma-related ED visits and/or hospitalizations. Results: There were 3,417 asthma-related ED visits and/or hospitalizations among 117,595 subjects with asthma. Statin users were significantly less likely to experience asthma-related ED visits and/or hospitalizations (adjusted hazard ratio: 0.81; 95% confidence interval: 0.74-0.89) compared with nonstatin users. The risks of asthma-related ED visits and/or hospitalizations were decreased among those with a higher cumulative defined daily dose (DDD), greater average DDD, and longer cumulative-day users than the counterparts. Conclusions: Our study suggests that statin use is associated with the decreased risk of asthma-related ED visits and/or hospitalizations in patients with asthma. A dose-response effect of statin use is also observed in this study. Therefore, future randomized clinical trials would be warranted to further evaluate the association.
AB - Background: Statins have pleiotropic anti-inflammatory and immunomodulatory effects, yet the effect of statin use on asthma-related emergency department (ED) visits and hospitalizations has remained unclear, especially in Asian populations. Objective: We sought to examine the effect of statin therapy on asthma-related ED visits and/or hospitalizations. Methods: A cohort study was conducted using data from Taiwan's National Health Insurance Research Database from 2001 to 2013. A total of 117,595 adult patients with asthma were included. The outcomes were defined as asthma-related ED visits and/or hospitalizations. Multiple Cox proportional hazards models were applied to determine the effect of statin use on asthma-related ED visits and/or hospitalizations. Results: There were 3,417 asthma-related ED visits and/or hospitalizations among 117,595 subjects with asthma. Statin users were significantly less likely to experience asthma-related ED visits and/or hospitalizations (adjusted hazard ratio: 0.81; 95% confidence interval: 0.74-0.89) compared with nonstatin users. The risks of asthma-related ED visits and/or hospitalizations were decreased among those with a higher cumulative defined daily dose (DDD), greater average DDD, and longer cumulative-day users than the counterparts. Conclusions: Our study suggests that statin use is associated with the decreased risk of asthma-related ED visits and/or hospitalizations in patients with asthma. A dose-response effect of statin use is also observed in this study. Therefore, future randomized clinical trials would be warranted to further evaluate the association.
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U2 - 10.1016/j.jaip.2017.12.017
DO - 10.1016/j.jaip.2017.12.017
M3 - Article
C2 - 29426752
AN - SCOPUS:85044943456
VL - 6
SP - 1588-1595.e1
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
SN - 2213-2198
IS - 5
ER -