Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: A nationwide population study in Taiwan

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Abstract

Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context. Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ≥18 years who were eligible for the Taiwan catastrophic illness certificate. The diagnoses, CHD outcomes and cardiovascular risk factors were identified from electronic claims data. We conducted two cohort analyses: CHD and DM, and CHD and PM, excluding for each analysis individuals with CHD already identified at baseline. Data for the comparison group was obtained from the Longitudinal Health Insurance database, comprising 1 million persons randomly sampled from the total beneficiaries during 2000. We estimated hazard ratios comparing myositis with comparison cohorts, adjusting for potential cardiovascular risk factors. Results: A total of 1145 patients with idiopathic myositis were identified, along with 732 723 control patients aged ≥18 years. The incidence rates of CHD were 15.1 in DM and 30.1 in PM per 1000 person-years, vs 8.4 and 10.5 per 1000 person-years in the comparison cohort. The adjusted hazard ratios for CHD in patients with idiopathic myositis were 2.21 (95% CI 1.64, 2.99) for DM and 3.73 (95% CI 2.83, 4.90) for PM. Conclusion: Results of this general population-based cohort study suggest that DM and PM are associated with an increased risk of CHD.

Original languageEnglish
Pages (from-to)1935-1941
Number of pages7
JournalRheumatology (United Kingdom)
Volume58
Issue number11
DOIs
Publication statusPublished - 2019 Nov 1

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Myositis
Taiwan
Coronary Disease
Population
Cohort Studies
Catastrophic Illness
Databases
National Health Programs
Health Insurance
Retrospective Studies
Incidence
Research

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

Cite this

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title = "Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis: A nationwide population study in Taiwan",
abstract = "Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context. Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ≥18 years who were eligible for the Taiwan catastrophic illness certificate. The diagnoses, CHD outcomes and cardiovascular risk factors were identified from electronic claims data. We conducted two cohort analyses: CHD and DM, and CHD and PM, excluding for each analysis individuals with CHD already identified at baseline. Data for the comparison group was obtained from the Longitudinal Health Insurance database, comprising 1 million persons randomly sampled from the total beneficiaries during 2000. We estimated hazard ratios comparing myositis with comparison cohorts, adjusting for potential cardiovascular risk factors. Results: A total of 1145 patients with idiopathic myositis were identified, along with 732 723 control patients aged ≥18 years. The incidence rates of CHD were 15.1 in DM and 30.1 in PM per 1000 person-years, vs 8.4 and 10.5 per 1000 person-years in the comparison cohort. The adjusted hazard ratios for CHD in patients with idiopathic myositis were 2.21 (95{\%} CI 1.64, 2.99) for DM and 3.73 (95{\%} CI 2.83, 4.90) for PM. Conclusion: Results of this general population-based cohort study suggest that DM and PM are associated with an increased risk of CHD.",
author = "Weng, {Meng Yu} and Lai, {Edward Chia Cheng} and Yang, {Yea Huei Kao}",
year = "2019",
month = "11",
day = "1",
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T1 - Increased risk of coronary heart disease among patients with idiopathic inflammatory myositis

T2 - A nationwide population study in Taiwan

AU - Weng, Meng Yu

AU - Lai, Edward Chia Cheng

AU - Yang, Yea Huei Kao

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context. Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ≥18 years who were eligible for the Taiwan catastrophic illness certificate. The diagnoses, CHD outcomes and cardiovascular risk factors were identified from electronic claims data. We conducted two cohort analyses: CHD and DM, and CHD and PM, excluding for each analysis individuals with CHD already identified at baseline. Data for the comparison group was obtained from the Longitudinal Health Insurance database, comprising 1 million persons randomly sampled from the total beneficiaries during 2000. We estimated hazard ratios comparing myositis with comparison cohorts, adjusting for potential cardiovascular risk factors. Results: A total of 1145 patients with idiopathic myositis were identified, along with 732 723 control patients aged ≥18 years. The incidence rates of CHD were 15.1 in DM and 30.1 in PM per 1000 person-years, vs 8.4 and 10.5 per 1000 person-years in the comparison cohort. The adjusted hazard ratios for CHD in patients with idiopathic myositis were 2.21 (95% CI 1.64, 2.99) for DM and 3.73 (95% CI 2.83, 4.90) for PM. Conclusion: Results of this general population-based cohort study suggest that DM and PM are associated with an increased risk of CHD.

AB - Objective: To evaluate the risk of incident coronary heart disease (CHD) among patients with DM and PM in a general population context. Methods: We conducted a retrospective cohort study using the Taiwan National Health Insurance Research Database containing records covering the years from 2000 to 2010. DM and PM were confined for the purposes of this study to those aged ≥18 years who were eligible for the Taiwan catastrophic illness certificate. The diagnoses, CHD outcomes and cardiovascular risk factors were identified from electronic claims data. We conducted two cohort analyses: CHD and DM, and CHD and PM, excluding for each analysis individuals with CHD already identified at baseline. Data for the comparison group was obtained from the Longitudinal Health Insurance database, comprising 1 million persons randomly sampled from the total beneficiaries during 2000. We estimated hazard ratios comparing myositis with comparison cohorts, adjusting for potential cardiovascular risk factors. Results: A total of 1145 patients with idiopathic myositis were identified, along with 732 723 control patients aged ≥18 years. The incidence rates of CHD were 15.1 in DM and 30.1 in PM per 1000 person-years, vs 8.4 and 10.5 per 1000 person-years in the comparison cohort. The adjusted hazard ratios for CHD in patients with idiopathic myositis were 2.21 (95% CI 1.64, 2.99) for DM and 3.73 (95% CI 2.83, 4.90) for PM. Conclusion: Results of this general population-based cohort study suggest that DM and PM are associated with an increased risk of CHD.

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