Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene

Sheng Yow Ho, Ying-Jan Wang, Hen Li Chen, Chih-Hung Chen, Chih-Jen Chang, Po Jen Wang, Helen H.W Chen, How-Ran Guo

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66 Citations (Scopus)

Abstract

Background and Aims: Tumor necrosis factor-α (TNF-α) is a cytokine that may act as an endogenous tumor promoter. A genetic polymorphism of TNF-α at position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 (-308A) alleles, has been found to be associated with susceptibility to various types of cancer. We conducted a study to evaluate the association between this polymorphism and hepatocellular carcinoma (HCC). Methods: We recruited 74 HCC patients and 289 healthy controls, and determined their -308 TNF-α promoter genotypes through polymerase chain reaction followed by electrophoresis. Results: Carriage of the TNF2 allele was associated with an increased risk of HCC (odds ratio [OR] = 3.5; 95% confidence interval [CI]:[2.1, 6.0]), and a trend toward a significant increase in the risk of developing HCC was observed from TNF1/TNF1, TNF1/TNF2, to TNF2/TNF2 genotypes (p < 0.01). After adjustment for gender, age, and markers of hepatitis B and C, the OR of developing HCC associated with TNF2 allele carriage was 5.3 (95% CI: [2.3, 12.1]; p < 0.01) Conclusions: Carriage of the TNF2 allele is a significant predictor of HCC independent of hepatitis B and C, and therefore it may be used as a biomarker for susceptibility to HCC.

Original languageEnglish
Pages (from-to)657-663
Number of pages7
JournalCancer Causes and Control
Volume15
Issue number7
DOIs
Publication statusPublished - 2004 Sep 1

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Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
Alleles
Genes
Hepatitis C
Hepatitis B
Odds Ratio
Genotype
Confidence Intervals
Genetic Polymorphisms
Genetic Promoter Regions
Carcinogens
Electrophoresis
Biomarkers
Cytokines
Polymerase Chain Reaction
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene",
abstract = "Background and Aims: Tumor necrosis factor-α (TNF-α) is a cytokine that may act as an endogenous tumor promoter. A genetic polymorphism of TNF-α at position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 (-308A) alleles, has been found to be associated with susceptibility to various types of cancer. We conducted a study to evaluate the association between this polymorphism and hepatocellular carcinoma (HCC). Methods: We recruited 74 HCC patients and 289 healthy controls, and determined their -308 TNF-α promoter genotypes through polymerase chain reaction followed by electrophoresis. Results: Carriage of the TNF2 allele was associated with an increased risk of HCC (odds ratio [OR] = 3.5; 95{\%} confidence interval [CI]:[2.1, 6.0]), and a trend toward a significant increase in the risk of developing HCC was observed from TNF1/TNF1, TNF1/TNF2, to TNF2/TNF2 genotypes (p < 0.01). After adjustment for gender, age, and markers of hepatitis B and C, the OR of developing HCC associated with TNF2 allele carriage was 5.3 (95{\%} CI: [2.3, 12.1]; p < 0.01) Conclusions: Carriage of the TNF2 allele is a significant predictor of HCC independent of hepatitis B and C, and therefore it may be used as a biomarker for susceptibility to HCC.",
author = "Ho, {Sheng Yow} and Ying-Jan Wang and Chen, {Hen Li} and Chih-Hung Chen and Chih-Jen Chang and Wang, {Po Jen} and Chen, {Helen H.W} and How-Ran Guo",
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TY - JOUR

T1 - Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter gene

AU - Ho, Sheng Yow

AU - Wang, Ying-Jan

AU - Chen, Hen Li

AU - Chen, Chih-Hung

AU - Chang, Chih-Jen

AU - Wang, Po Jen

AU - Chen, Helen H.W

AU - Guo, How-Ran

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Background and Aims: Tumor necrosis factor-α (TNF-α) is a cytokine that may act as an endogenous tumor promoter. A genetic polymorphism of TNF-α at position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 (-308A) alleles, has been found to be associated with susceptibility to various types of cancer. We conducted a study to evaluate the association between this polymorphism and hepatocellular carcinoma (HCC). Methods: We recruited 74 HCC patients and 289 healthy controls, and determined their -308 TNF-α promoter genotypes through polymerase chain reaction followed by electrophoresis. Results: Carriage of the TNF2 allele was associated with an increased risk of HCC (odds ratio [OR] = 3.5; 95% confidence interval [CI]:[2.1, 6.0]), and a trend toward a significant increase in the risk of developing HCC was observed from TNF1/TNF1, TNF1/TNF2, to TNF2/TNF2 genotypes (p < 0.01). After adjustment for gender, age, and markers of hepatitis B and C, the OR of developing HCC associated with TNF2 allele carriage was 5.3 (95% CI: [2.3, 12.1]; p < 0.01) Conclusions: Carriage of the TNF2 allele is a significant predictor of HCC independent of hepatitis B and C, and therefore it may be used as a biomarker for susceptibility to HCC.

AB - Background and Aims: Tumor necrosis factor-α (TNF-α) is a cytokine that may act as an endogenous tumor promoter. A genetic polymorphism of TNF-α at position -308 of the promoter region, which includes TNF1 (-308G) and TNF2 (-308A) alleles, has been found to be associated with susceptibility to various types of cancer. We conducted a study to evaluate the association between this polymorphism and hepatocellular carcinoma (HCC). Methods: We recruited 74 HCC patients and 289 healthy controls, and determined their -308 TNF-α promoter genotypes through polymerase chain reaction followed by electrophoresis. Results: Carriage of the TNF2 allele was associated with an increased risk of HCC (odds ratio [OR] = 3.5; 95% confidence interval [CI]:[2.1, 6.0]), and a trend toward a significant increase in the risk of developing HCC was observed from TNF1/TNF1, TNF1/TNF2, to TNF2/TNF2 genotypes (p < 0.01). After adjustment for gender, age, and markers of hepatitis B and C, the OR of developing HCC associated with TNF2 allele carriage was 5.3 (95% CI: [2.3, 12.1]; p < 0.01) Conclusions: Carriage of the TNF2 allele is a significant predictor of HCC independent of hepatitis B and C, and therefore it may be used as a biomarker for susceptibility to HCC.

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