Indices of aortic stiffness in mice

Anilkumar K. Reddy, Yi Heng Li, Thuy T. Pham, George E. Taffet, Lloyd H. Michael, Mark L. Entman, Craig J. Hartley

Research output: Contribution to journalConference articlepeer-review

Abstract

Ascending aortic input impedance spectra and pressure augmentation index was determined in young (8-month) and old (29-month) mice to see if arterial stiffening occurred with age in mice as it does in humans. Pressure and blood velocity signals measured simultaneously from the same location in the ascending aorta of a mouse were used to determine input impedance spectra (DC-10 harmonics). The first minimum of the impedance modulus shifted from the 2nd harmonic in young mice to the 4th harmonic in old mice. Characteristic impedance (estimated as average of 2nd 10 th harmonic) was significantly higher in old mice (mean±SEM, 471±62 vs. 299±10 dynes-s/cm3, p<0.05). Pulse pressure and augmentation index, determined from the aortic pressure signals were also higher in old mice: pulse pressure (42±2.2 vs. 29±4.9 mmHg, p<0.05) and augmentation index (37±5 vs. 14±2%, p<0.005). These results are similar to the findings reported in humans and confirm that mice may be used as models of age-related vascular stiffening.

Original languageEnglish
Pages (from-to)276-278
Number of pages3
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
Publication statusPublished - 2003
EventA New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: 2003 Sep 172003 Sep 21

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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