Indispensability of the Escherichia coli Carbonic Anhydrases YadF and CynT in Cell Proliferation at a Low CO2 Partial Pressure

Masayuki Hashimoto, Jun Ichi Kato

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We found that a carbonic anhydrase, YadF, is essential for cell growth in the absence of another carbonic anhydrase, CynT, in Escherichia coli. However, mutant strains lacking both of them grew at high CO2 concentrations (5%), where non-enzymatic mechanisms generate HCO3. This suggests that these carbonic anhydrases are essential because they maintain HCO3 levels at ambient CO2 concentrations.

Original languageEnglish
Pages (from-to)919-922
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume67
Issue number4
DOIs
Publication statusPublished - 2003 Jan 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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