Induction of liver fibrosis in a murine hepatoma model by thioacetamide is associated with enhanced tumor growth and suppressed antitumor immunity

Ming Chen Yang, Chih-Peng Chang, Huan Yao Lei

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Liver cirrhosis and hepatocellular carcinomas are two major causes of morbidity and mortality worldwide, and can synergistically interact to expedite the tumor progression. How fibrosis promotes the hepatoma growth remains completely unexplained. Using an in situ murine hepatoma model together with fibrosis induction by thioacetamide (TAA), the hepatoma growth and the immune factors in the fibrotic liver were analyzed. We found that TAA-fibrosis induction enhanced hepatoma cell growth in the liver and increased the mortality of hepatoma-bearing mice. The tumor-infiltrating CD4 or CD8 T cells are downregulated by fibrosis induction. The Foxp3 regulatory T cells (Treg) cells were induced. We conclude that fibrosis induction causes further immunosuppression, in which Treg cells exert a downregulation effect on the antitumor immunity.

Original languageEnglish
Pages (from-to)1782-1793
Number of pages12
JournalLaboratory Investigation
Volume90
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Thioacetamide
Liver Cirrhosis
Hepatocellular Carcinoma
Immunity
Fibrosis
Regulatory T-Lymphocytes
Growth
Neoplasms
Down-Regulation
Mortality
Liver
Immunologic Factors
Immunosuppression
Intercellular Signaling Peptides and Proteins
Morbidity
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

Cite this

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abstract = "Liver cirrhosis and hepatocellular carcinomas are two major causes of morbidity and mortality worldwide, and can synergistically interact to expedite the tumor progression. How fibrosis promotes the hepatoma growth remains completely unexplained. Using an in situ murine hepatoma model together with fibrosis induction by thioacetamide (TAA), the hepatoma growth and the immune factors in the fibrotic liver were analyzed. We found that TAA-fibrosis induction enhanced hepatoma cell growth in the liver and increased the mortality of hepatoma-bearing mice. The tumor-infiltrating CD4 or CD8 T cells are downregulated by fibrosis induction. The Foxp3 regulatory T cells (Treg) cells were induced. We conclude that fibrosis induction causes further immunosuppression, in which Treg cells exert a downregulation effect on the antitumor immunity.",
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Induction of liver fibrosis in a murine hepatoma model by thioacetamide is associated with enhanced tumor growth and suppressed antitumor immunity. / Yang, Ming Chen; Chang, Chih-Peng; Lei, Huan Yao.

In: Laboratory Investigation, Vol. 90, No. 12, 01.12.2010, p. 1782-1793.

Research output: Contribution to journalArticle

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