Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level

Shu Jen Han, Chien Chung Tsai, Hong-Ming Tsai, Yung Jung Chen

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Infantile hemangioendothelioma is the meet common vascular tumor in infancy. A three-month-old infant was admitted to the hospital for hepatomegaly. Abdominal ultrasonography, a CT-scan, and MRI studies demonstrated bilateral diffuse hepatic nodules, which were characteristic of hepatic hemangioendothelioma. A highly elevated alpha-fetoprotein (AFP) level misled us to an impression of hepatoblastoma, but the pathology report through an open biopsy disclosed a liver hemangioendothelioma. The patient responded to methylprednisolone therapy. A follow-up sonogram revealed regression of the hepatic masses. This case emphasizes that an elevated AFP level of up to 400 ng/ml is normally found in some neonates until two months of age. Careful interpretation of this value is very important, especially when it is associated with a hepatic tumor. Herein, we present a case of infantile hemangioendothelioma in a three-month-old boy with a highly elevated serum AFP.

Original languageEnglish
Pages (from-to)459-461
Number of pages3
Issue number20
Publication statusPublished - 1998 Apr 27

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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