Influence analysis on crossover design experiment in bioequivalence studies

Yufen Huang, Bo Shiang Ke

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Crossover designs are commonly used in bioequivalence studies. However, the results can be affected by some outlying observations, which may lead to the wrong decision on bioequivalence. Therefore, it is essential to investigate the influence of aberrant observations. Chow and Tse in 1990 discussed this issue by considering the methods based on the likelihood distance and estimates distance. Perturbation theory provides a useful tool for the sensitivity analysis on statistical models. Hence, in this paper, we develop the influence functions via the perturbation scheme proposed by Hampel as an alternative approach on the influence analysis for a crossover design experiment. Moreover, the comparisons between the proposed approach and the method proposed by Chow and Tse are investigated. Two real data examples are provided to illustrate the results of these approaches. Our proposed influence functions show excellent performance on the identification of outlier/influential observations and are suitable for use with small sample size crossover designs commonly used in bioequivalence studies.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalPharmaceutical Statistics
Volume13
Issue number2
DOIs
Publication statusPublished - 2014 Mar 1

Fingerprint

Bioequivalence
Influence Analysis
Crossover Design
Therapeutic Equivalency
Cross-Over Studies
Influence Function
Influential Observations
Experiment
Small Sample Size
Statistical Models
Sample Size
Perturbation Theory
Statistical Model
Outlier
Sensitivity Analysis
Likelihood
Perturbation
Alternatives
Estimate
Observation

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

Cite this

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Influence analysis on crossover design experiment in bioequivalence studies. / Huang, Yufen; Ke, Bo Shiang.

In: Pharmaceutical Statistics, Vol. 13, No. 2, 01.03.2014, p. 110-118.

Research output: Contribution to journalArticle

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