Inhibition of antibody production from the plasmacytoma cell line MOPC-315 by staphylococcal enterotoxin B-induced T-suppressor cells

Yee Shin Lin, Thomas J. Rogers

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Our previous results have shown that Staphylococcal enterotoxin B (SEB) induces a population (s) of T cells which has the capacity to suppress the antibody response of splenocytes in vitro. In the present report we have attempted to investigate the effect of SEB-primed cells on the secretion of antibody by the plasmacytoma cell line MOPC-315. We have found that the secretion of antibody by MOPC-315 is significantly reduced in as little as 24 hr of coculture with the suppressor cells. The suppressive activity is not antigen- or isotype-specific, since the antibody secretion by both MPC-11 and HOPC1 plasmacytomas are also inhibited by the SEB-primed cells. In addition, we have found that the SEB-primed cell population which inhibits the antibody production by the MOPC-315 cell line expresses the Lyt-1+,2- and Thy-1+ cell surface markers. The apparent relationship between the SEB-primed suppressor cell population and the population which inhibits a conventional antibody response is discussed.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalCellular Immunology
Volume102
Issue number2
DOIs
Publication statusPublished - 1986 Oct 15

All Science Journal Classification (ASJC) codes

  • Immunology

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