Inhibition of calcium channels in rat hippocampal CA1 neurons by conantokin-T

Kuei-Sen Hsu, Chiung Chun Huang, Ping Chiang Lyu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Effects of conantokin-T, a 21 amino acid peptide toxin isolated from the fish-hunting cone snail Conus tulipa, on the high-voltage-activated Ca2+ channel currents were studied in acutely dissociated rat hippocampal CA1 neurons using whole-cell voltage clamp-recording technique with 5 mM Ba2+ as the charge carrier. Conantokin-T inhibited the whole-cell Ba2+ current (I(Ba)) in a concentration-dependent manner. The nimodipine (20 μM) and ω-agatoxin-IVA (0.2 μM) block of I(Ba) were abolished in the presence of conantokin-T (3 μM); however, conantokin-T (3 μM) did not affect the block of I(Ba) induced by 3 μM ω-conotoxin-GVIA. These results indicate that conantokin-T is a potent but wide-spectrum Ca2+ channel antagonist.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Volume220
Issue number2
DOIs
Publication statusPublished - 1996 Dec 13

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Calcium Channels
Neurons
Agatoxins
Tulipa
Conotoxins
Conus Snail
Nimodipine
Patch-Clamp Techniques
Fishes
conantokin-T
Amino Acids
Peptides

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hsu, Kuei-Sen ; Huang, Chiung Chun ; Lyu, Ping Chiang. / Inhibition of calcium channels in rat hippocampal CA1 neurons by conantokin-T. In: Neuroscience Letters. 1996 ; Vol. 220, No. 2. pp. 113-116.
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Inhibition of calcium channels in rat hippocampal CA1 neurons by conantokin-T. / Hsu, Kuei-Sen; Huang, Chiung Chun; Lyu, Ping Chiang.

In: Neuroscience Letters, Vol. 220, No. 2, 13.12.1996, p. 113-116.

Research output: Contribution to journalArticle

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