Inhibition of middle cerebral artery occlusion-induced focal cerebral ischemia by carboxyfullerene

Y. H. Wang, E. J. Lee, C. M. Wu, T. Y. Luh, C. K. Chou, H. Y. Lei

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The neuroprotective effects of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, were evaluated in mice subjected to permanent middle cerebral artery occlusion (MCAO). The ischemic disruption of the blood-brain barrier (BBB) was shown by its permeability to the peripheral M4 tracer and the damage of endothelial cells. Cytokines TNF-α and IL-1β were expressed on arterioles. Relatively to vehicle-treated controls, mice treated with carboxyfullerene (40 mg/kg) at the time of ischemia showed a 75% reduction in brain infarction. This inhibition was dose- and time-dependent. There was still significant inhibition 6 h post-occlusion. With anti-carboxyfullerene antibody immunohistochemical staining, carboxyfullerene was detectable on the neurons and ventricle in the ipsilateral hemisphere of the carboxyfullerene-treated mice. This suggests that carboxyfullerene can be a potential therapeutic agent for MCAO-induced focal cerebral ischemia treatment.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalJournal of Drug Delivery Science and Technology
Volume14
Issue number1
DOIs
Publication statusPublished - 2004

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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