Inhibition of platelet thromboxane formation and phosphoinositide breakdown by osthole from Angelica pubescens

F. N. Ko, T. S. Wu, M. J. Liou, T. F. Huang, C. M. Teng

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Osthole, isolated from Chinese herb Angelica pubescencs, inhibited platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. It showed a weak activity in platelet-rich plasma. Osthole inhibited the thromboxane B2 formation caused by arachidonic acid, collagen, ionophore A23187 and thrombin in washed platelets, and also the thromboxane B2 formation caused by the incubation of lysed platelet homogenate with arachidonic acid. The generation of inositol phosphates in washed platelets caused by collagen, PAF and thrombin was suppressed by osthole. These data indicate that the inhibitory effect of osthole on platelet aggregation and release reaction was due to the inhibition of thromboxane formation and phosphoinositides breakdown.

Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalThrombosis and Haemostasis
Volume62
Issue number3
DOIs
Publication statusPublished - 1989

All Science Journal Classification (ASJC) codes

  • Hematology

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