TY - JOUR
T1 - Inhibition of platelet thromboxane formation and phosphoinositide breakdown by osthole from Angelica pubescens
AU - Ko, F. N.
AU - Wu, T. S.
AU - Liou, M. J.
AU - Huang, T. F.
AU - Teng, C. M.
PY - 1989
Y1 - 1989
N2 - Osthole, isolated from Chinese herb Angelica pubescencs, inhibited platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. It showed a weak activity in platelet-rich plasma. Osthole inhibited the thromboxane B2 formation caused by arachidonic acid, collagen, ionophore A23187 and thrombin in washed platelets, and also the thromboxane B2 formation caused by the incubation of lysed platelet homogenate with arachidonic acid. The generation of inositol phosphates in washed platelets caused by collagen, PAF and thrombin was suppressed by osthole. These data indicate that the inhibitory effect of osthole on platelet aggregation and release reaction was due to the inhibition of thromboxane formation and phosphoinositides breakdown.
AB - Osthole, isolated from Chinese herb Angelica pubescencs, inhibited platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. It showed a weak activity in platelet-rich plasma. Osthole inhibited the thromboxane B2 formation caused by arachidonic acid, collagen, ionophore A23187 and thrombin in washed platelets, and also the thromboxane B2 formation caused by the incubation of lysed platelet homogenate with arachidonic acid. The generation of inositol phosphates in washed platelets caused by collagen, PAF and thrombin was suppressed by osthole. These data indicate that the inhibitory effect of osthole on platelet aggregation and release reaction was due to the inhibition of thromboxane formation and phosphoinositides breakdown.
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U2 - 10.1055/s-0038-1651041
DO - 10.1055/s-0038-1651041
M3 - Article
C2 - 2556815
AN - SCOPUS:0024355793
VL - 62
SP - 996
EP - 999
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 3
ER -