Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Chang Jer Wu; Jia Tsrong Jan; Chi Min Chen; Hsing Pang Hsieh; Der Ren Hwang; Hwan Wun Liu; Chiu Yi Liu; Hui Wen Huang; Su Chin Chen; Cheng Fong Hong; Ren Kuo Lin; Yu Sheng Chao; John T.A. Hsu

doi:10.1128/AAC.48.7.2693-2696.2004

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Chang Jer Wu, Jia Tsrong Jan, Chi Min Chen, Hsing Pang Hsieh, Der Ren Hwang, Hwan Wun Liu, Chiu Yi Liu, Hui Wen Huang, Su Chin Chen, Cheng Fong Hong, Ren Kuo Lin, Yu Sheng Chao, John T.A. Hsu

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

177 Citations (Scopus)

Abstract

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

Original language	English
Pages (from-to)	2693-2696
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	48
Issue number	7
DOIs	https://doi.org/10.1128/AAC.48.7.2693-2696.2004
Publication status	Published - 2004 Jul

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.48.7.2693-2696.2004

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title = "Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide",

abstract = "Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.",

author = "Wu, {Chang Jer} and Jan, {Jia Tsrong} and Chen, {Chi Min} and Hsieh, {Hsing Pang} and Hwang, {Der Ren} and Liu, {Hwan Wun} and Liu, {Chiu Yi} and Huang, {Hui Wen} and Chen, {Su Chin} and Hong, {Cheng Fong} and Lin, {Ren Kuo} and Chao, {Yu Sheng} and Hsu, {John T.A.}",

year = "2004",

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T1 - Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

AU - Wu, Chang Jer

AU - Jan, Jia Tsrong

AU - Chen, Chi Min

AU - Hsieh, Hsing Pang

AU - Hwang, Der Ren

AU - Liu, Hwan Wun

AU - Liu, Chiu Yi

AU - Huang, Hui Wen

AU - Chen, Su Chin

AU - Hong, Cheng Fong

AU - Lin, Ren Kuo

AU - Chao, Yu Sheng

AU - Hsu, John T.A.

PY - 2004/7

Y1 - 2004/7

N2 - Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

AB - Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 μM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

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Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

Abstract

All Science Journal Classification (ASJC) codes

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