Inhibition of Th2 cytokine production in T cells by monascin via PPAR-γ activation

Wei Hsuan Hsu, Bao Hong Lee, Ya Wen Hsu, Tzu Ming Pan

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7 Citations (Scopus)

Abstract

Yellow pigment monascin (MS) is a secondary metabolite isolated from Monascus-fermented products and has numerous physiological activities. However, the potential use of MS for immunomodulation remains unclear. We showed that MS and the synthetic peroxisome proliferator-activated receptor (PPAR)-γ ligand rosiglitazone (RG) significantly inhibited the production of Th2 cytokines, including IL-4, IL-5, and IL-13, in PMA/ionomycin-activated mouse EL-4 T cells. Moreover, we showed that this was due to cellular PPAR-γ translocation. These results indicate that MS and RG promote PPAR-γ-DNA interactions and suggest that the regulatory effects of MS and RG on Th2 cytokine production could be abolished with PPAR-γ antagonist treatment. MS and RG also suppressed Th2 transcription factor translocation (e.g., GATA-3 and nuclear factor of activated T cells) by preventing the phosphorylation of protein kinase C and signal transducer and activator of transcription 6.

Original languageEnglish
Pages (from-to)8126-8133
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume61
Issue number34
DOIs
Publication statusPublished - 2013 Aug 28

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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