Inhibition of the increased permeability of blood-brain barrier in escherichia coli-induced meningitis by carboxyfullerene

Nina Tsao, Ching Ming Wu, Hui Ping Hsu, Ching Chuan Liu, Tien Yau Luh, Chen Kung Chou, Huan Yao Lei

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene (C63(COOH)6), on the opening of blood-brain barrier (BBB) in Escherichia coli (E. coli)-induced meningitis was tested. In E. coli-induced meningitis model, the increase of BBB permeability was manifested in two distinct phases based on cytokine expression pattern and neutrophilic infiltration in B6 mice. An early increase in BBB permeability was occurred at 1-5 h post injection that could be blocked by either anti-TNF-α or anti-IL-1β antibodies. A late one (neutrophil-associated BBB opening) was manifested at 6-12 h that was inhibited by vinblastine pretreatment. Inhibition of the early E. coli-induced BBB opening blocked the development of the late one. Furthermore, the neutrophil-associated BBB opening (the late phase), but not cytokine-induced one (the early phase), was inhibited by a water-soluble carboxyfullerene.

Original languageEnglish
Pages (from-to)307-320
Number of pages14
JournalFullerene Science and Technology
Volume9
Issue number3
DOIs
Publication statusPublished - 2001 Aug

Fingerprint

meningitis
blood-brain barrier
Escherichia
Escherichia coli
permeability
neutrophils
Cytokines
Fullerenes
Vinblastine
Water
infiltration
antibodies
Interleukin-1
Infiltration
Antibodies
pretreatment
water
fullerenes
mice
Blood-Brain Barrier

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)

Cite this

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title = "Inhibition of the increased permeability of blood-brain barrier in escherichia coli-induced meningitis by carboxyfullerene",
abstract = "The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene (C63(COOH)6), on the opening of blood-brain barrier (BBB) in Escherichia coli (E. coli)-induced meningitis was tested. In E. coli-induced meningitis model, the increase of BBB permeability was manifested in two distinct phases based on cytokine expression pattern and neutrophilic infiltration in B6 mice. An early increase in BBB permeability was occurred at 1-5 h post injection that could be blocked by either anti-TNF-α or anti-IL-1β antibodies. A late one (neutrophil-associated BBB opening) was manifested at 6-12 h that was inhibited by vinblastine pretreatment. Inhibition of the early E. coli-induced BBB opening blocked the development of the late one. Furthermore, the neutrophil-associated BBB opening (the late phase), but not cytokine-induced one (the early phase), was inhibited by a water-soluble carboxyfullerene.",
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Inhibition of the increased permeability of blood-brain barrier in escherichia coli-induced meningitis by carboxyfullerene. / Tsao, Nina; Wu, Ching Ming; Hsu, Hui Ping; Liu, Ching Chuan; Luh, Tien Yau; Chou, Chen Kung; Lei, Huan Yao.

In: Fullerene Science and Technology, Vol. 9, No. 3, 08.2001, p. 307-320.

Research output: Contribution to journalArticle

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AU - Luh, Tien Yau

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AU - Lei, Huan Yao

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