Inhibitory effects of Bichalcone derivatives on Superoxide anion generation (O2 •-) and elastase release by activated human neutrophils in response to FMLP/CB

Mopur Vijaya Bhaskar Reddy, Tsong Long Hwang, Tian Shung Wu

Research output: Contribution to journalArticle

Abstract

Chalcones have a distinctive 1,3-diaryl propenone skeleton and exert numerous biological effects. Previously we synthesized (1a-23) bichalcones through the piperazine Mannich base linkage with different substitution on the both ring-B of the chalcone moieties. These compounds were subjected into the inhibitory effects on Formyl-Met-Leu-Phe (FMLP) and cytochalasin B (CB) stimulated O2 •- generation and elastase release in human neutrophils. Among the tested compounds, 3-23 were exhibited potent elastase release inhibitory effects in activated human neutrophils with the IC50 values ranges from 4.98 μM to 50.87 μM.

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalDer Pharmacia Lettre
Volume8
Issue number20
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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