Injectable thermosensitive hydrogels for intratumor release depot and embolization agent

K. Y. Chang, P. Kan, M. H. Yeh, M. F. Hsieh, S. H. Jan, Xi-Zhang Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several kinds of PLGA-based biodegradable thermosentive polymers have been synthesized. The reversible sol-gel transition were characterized by viscosity measurement and revealed that LCST of these polymers were in the range of 15-25°C. Drug release behavior in the polymer gels has been conducted in vitro with Paclitaxel as a model compound. In the case of loading paclitaxel, addition of a hydrophobic component (lipiodol®) in the system seemed to get a better release profile. This study also shows intra-tumor injection of hydrogel-lipiodol mixture is very promising for the treatment of liver cancer. Besides, the potential for these thermosensitive polymers to be applied as embolization agent has been carried out in vivo in a rabbit model.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - 2004 Dec 1
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 2004 May 172004 May 21

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period04-05-1704-05-21

Fingerprint

Hydrogels
Polymers
Biodegradable polymers
Viscosity measurement
Liver
Sol-gels
Tumors
Gels

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Chang, K. Y., Kan, P., Yeh, M. H., Hsieh, M. F., Jan, S. H., & Lin, X-Z. (2004). Injectable thermosensitive hydrogels for intratumor release depot and embolization agent. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).
Chang, K. Y. ; Kan, P. ; Yeh, M. H. ; Hsieh, M. F. ; Jan, S. H. ; Lin, Xi-Zhang. / Injectable thermosensitive hydrogels for intratumor release depot and embolization agent. Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).
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abstract = "Several kinds of PLGA-based biodegradable thermosentive polymers have been synthesized. The reversible sol-gel transition were characterized by viscosity measurement and revealed that LCST of these polymers were in the range of 15-25°C. Drug release behavior in the polymer gels has been conducted in vitro with Paclitaxel as a model compound. In the case of loading paclitaxel, addition of a hydrophobic component (lipiodol{\circledR}) in the system seemed to get a better release profile. This study also shows intra-tumor injection of hydrogel-lipiodol mixture is very promising for the treatment of liver cancer. Besides, the potential for these thermosensitive polymers to be applied as embolization agent has been carried out in vivo in a rabbit model.",
author = "Chang, {K. Y.} and P. Kan and Yeh, {M. H.} and Hsieh, {M. F.} and Jan, {S. H.} and Xi-Zhang Lin",
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Chang, KY, Kan, P, Yeh, MH, Hsieh, MF, Jan, SH & Lin, X-Z 2004, Injectable thermosensitive hydrogels for intratumor release depot and embolization agent. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 04-05-17.

Injectable thermosensitive hydrogels for intratumor release depot and embolization agent. / Chang, K. Y.; Kan, P.; Yeh, M. H.; Hsieh, M. F.; Jan, S. H.; Lin, Xi-Zhang.

Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Chang, K. Y.

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AB - Several kinds of PLGA-based biodegradable thermosentive polymers have been synthesized. The reversible sol-gel transition were characterized by viscosity measurement and revealed that LCST of these polymers were in the range of 15-25°C. Drug release behavior in the polymer gels has been conducted in vitro with Paclitaxel as a model compound. In the case of loading paclitaxel, addition of a hydrophobic component (lipiodol®) in the system seemed to get a better release profile. This study also shows intra-tumor injection of hydrogel-lipiodol mixture is very promising for the treatment of liver cancer. Besides, the potential for these thermosensitive polymers to be applied as embolization agent has been carried out in vivo in a rabbit model.

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Chang KY, Kan P, Yeh MH, Hsieh MF, Jan SH, Lin X-Z. Injectable thermosensitive hydrogels for intratumor release depot and embolization agent. In Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).