Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen, Hsiu Chen Lin, Hsi Hsien Chen, Fu Der Mai, Yu Chuan Liu, Chun Mao Lin, Chun Chao Chang, Hui Yen Tsai, Chih Ping Yang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Original languageEnglish
Article number4425
JournalScientific reports
Volume4
DOIs
Publication statusPublished - 2014 Mar 21

All Science Journal Classification (ASJC) codes

  • General

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