Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen; Hsiu Chen Lin; Hsi Hsien Chen; Fu Der Mai; Yu Chuan Liu; Chun Mao Lin; Chun Chao Chang; Hui Yen Tsai; Chih Ping Yang

doi:10.1038/srep04425

Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao Chien Chen, Hsiu Chen Lin, Hsi Hsien Chen, Fu Der Mai, Yu Chuan Liu, Chun Mao Lin, Chun Chao Chang, Hui Yen Tsai, Chih Ping Yang

Center of Applied Nanomedicine

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K₃ Fe(CN)₆ in saline solution can be significantly increased from 2.76, to 4.62 × 10^-6 cm s^-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Original language	English
Article number	4425
Journal	Scientific reports
Volume	4
DOIs	https://doi.org/10.1038/srep04425
Publication status	Published - 2014 Mar 21

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title = "Innovative strategy with potential to increase hemodialysis efficiency and safety",

abstract = "Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.",

author = "Chen, {Hsiao Chien} and Lin, {Hsiu Chen} and Chen, {Hsi Hsien} and Mai, {Fu Der} and Liu, {Yu Chuan} and Lin, {Chun Mao} and Chang, {Chun Chao} and Tsai, {Hui Yen} and Yang, {Chih Ping}",

note = "Funding Information: The authors thank the National Science Council of ROC and Taipei Medical University for their financial support.",

year = "2014",

month = mar,

day = "21",

doi = "10.1038/srep04425",

language = "English",

volume = "4",

journal = "Scientific reports",

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T1 - Innovative strategy with potential to increase hemodialysis efficiency and safety

AU - Chen, Hsiao Chien

AU - Lin, Hsiu Chen

AU - Chen, Hsi Hsien

AU - Mai, Fu Der

AU - Liu, Yu Chuan

AU - Lin, Chun Mao

AU - Chang, Chun Chao

AU - Tsai, Hui Yen

AU - Yang, Chih Ping

N1 - Funding Information: The authors thank the National Science Council of ROC and Taipei Medical University for their financial support.

PY - 2014/3/21

Y1 - 2014/3/21

N2 - Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

AB - Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3 Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10-6 cm s-1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

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Innovative strategy with potential to increase hemodialysis efficiency and safety

Abstract

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