Insights into copper effect on Proteus hauseri through proteomic and metabolic analyses

I. Son Ng, Chiming Ye, Yuzhe Li, Bor Yann Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


This is the first-attempt to use liquid chromatography coupled with tandem mass (LC-MS-MS) in deciphering the effects of copper ion on Proteus hauseri. Total 941 proteins in copper-addition (+Cu) group and 898 proteins in non-copper-addition (-Cu) group were found, which containing 221 and 178 differential proteins in +Cu and -Cu group, respectively. Differential proteins in both groups were defined into 14 groups by their functional classification which transport/membrane function proteins were the major different part between the two groups, which took 19.5% and 7.7%, respectively. The result of BioCyc and KEGG analyses on metabolic pathway indicated that copper could interrupted the pathway of chemotaxis CheY and inhibited the swarming of P. hauseri, which provided a potential in controlling the pathogenicity of this strain.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalJournal of Bioscience and Bioengineering
Issue number2
Publication statusPublished - 2016 Feb 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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