Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu; Hung Tsung Wu; Yi Hsuan Hsiao; Chih Wei Lai; Chun Wei Shih; Yung Kang Peng; Kuo Chun Tang; Hsing Wei Chang; Yun Chen Chien; Jong Kai Hsiao; Juei Tang Cheng; Pi Tai Chou

doi:10.1002/anie.201100299

Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Chien Liang Liu, Hung Tsung Wu, Yi Hsuan Hsiao, Chih Wei Lai, Chun Wei Shih, Yung Kang Peng, Kuo Chun Tang, Hsing Wei Chang, Yun Chen Chien, Jong Kai Hsiao, Juei Tang Cheng, Pi Tai Chou

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

375 Citations (Scopus)

Abstract

Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

Original language	English
Pages (from-to)	7056-7060
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	31
DOIs	https://doi.org/10.1002/anie.201100299
Publication status	Published - 2011 Jul 25

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

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10.1002/anie.201100299

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Liu, C. L., Wu, H. T., Hsiao, Y. H., Lai, C. W., Shih, C. W., Peng, Y. K., Tang, K. C., Chang, H. W., Chien, Y. C., Hsiao, J. K., Cheng, J. T., & Chou, P. T. (2011). Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angewandte Chemie - International Edition, 50(31), 7056-7060. https://doi.org/10.1002/anie.201100299

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abstract = "Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).",

author = "Liu, {Chien Liang} and Wu, {Hung Tsung} and Hsiao, {Yi Hsuan} and Lai, {Chih Wei} and Shih, {Chun Wei} and Peng, {Yung Kang} and Tang, {Kuo Chun} and Chang, {Hsing Wei} and Chien, {Yun Chen} and Hsiao, {Jong Kai} and Cheng, {Juei Tang} and Chou, {Pi Tai}",

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doi = "10.1002/anie.201100299",

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Liu, CL, Wu, HT, Hsiao, YH, Lai, CW, Shih, CW, Peng, YK, Tang, KC, Chang, HW, Chien, YC, Hsiao, JK, Cheng, JT & Chou, PT 2011, 'Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging', Angewandte Chemie - International Edition, vol. 50, no. 31, pp. 7056-7060. https://doi.org/10.1002/anie.201100299

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AU - Liu, Chien Liang

AU - Wu, Hung Tsung

AU - Hsiao, Yi Hsuan

AU - Lai, Chih Wei

AU - Shih, Chun Wei

AU - Peng, Yung Kang

AU - Tang, Kuo Chun

AU - Chang, Hsing Wei

AU - Chien, Yun Chen

AU - Hsiao, Jong Kai

AU - Cheng, Juei Tang

AU - Chou, Pi Tai

PY - 2011/7/25

Y1 - 2011/7/25

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AB - Go for gold: As-prepared insulin-Au nanoclusters (NCs) show intense red fluorescence, excellent biocompatibility, and preservation of natural insulin bioactivity in lowering the blood-glucose level. Their versatility in applications is demonstrated by fluorescence imaging, X-ray computed tomography, and insulin-inhibitor interactions (see picture; IDE=insulin-degrading enzyme).

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JF - Angewandte Chemie - International Edition

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Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging

Abstract

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