Integrated Omics of Metastatic Colorectal Cancer

Chen Li, Yi Di Sun, Guan Yu Yu, Jing Ru Cui, Zheng Lou, Hang Zhang, Ya Huang, Chen Guang Bai, Lu Lu Deng, Peng Liu, Kuo Zheng, Yan Hua Wang, Qin Qin Wang, Qing Run Li, Qing Qing Wu, Qi Liu, Yu Shyr, Yi Xue Li, Luo Nan Chen, Jia Rui WuWei Zhang, Rong Zeng

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We integrate the genomics, proteomics, and phosphoproteomics of 480 clinical tissues from 146 patients in a Chinese colorectal cancer (CRC) cohort, among which 70 had metastatic CRC (mCRC). Proteomic profiling differentiates three CRC subtypes characterized by distinct clinical prognosis and molecular signatures. Proteomic and phosphoproteomic profiling of primary tumors alone successfully distinguishes cases with metastasis. Metastatic tissues exhibit high similarities with primary tumors at the genetic but not the proteomic level, and kinase network analysis reveals significant heterogeneity between primary colorectal tumors and their liver metastases. In vivo xenograft-based drug tests using 31 primary and metastatic tumors show personalized responses, which could also be predicted by kinase-substrate network analysis no matter whether tumors carry mutations in the drug-targeted genes. Our study provides a valuable resource for better understanding of mCRC and has potential for clinical application.

Original languageEnglish
Pages (from-to)734-747.e9
JournalCancer Cell
Volume38
Issue number5
DOIs
Publication statusPublished - 2020 Nov 9

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cell Biology
  • Cancer Research

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