Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). Materials and methods: From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared. Results: The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2% vs. 69.4% (p = 0.079), respectively. The 3-year local-regional control (53.5% vs. 76.3%; p = 0.020) and disease-free survival rates (47.8% vs. 70.0%; p = 0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (≤2 mm), more advanced T stage (T3-4 vs. T1-2), and conventional RT method were associated with worse prognosis. Conclusions: The addition of chemotherapy to adjuvant radiotherapy is recommended in patients with above risk factors. Our result underscores that IMRT should be considered to apply to OSCC patients referred for postoperative treatment.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalOral Oncology
Volume48
Issue number8
DOIs
Publication statusPublished - 2012 Aug 1

Fingerprint

Intensity-Modulated Radiotherapy
Mouth
Squamous Cell Carcinoma
Radiotherapy
Survival Rate
Adjuvant Radiotherapy
Radiation Oncology
Survival
Mouth Neoplasms
Kaplan-Meier Estimate
Disease-Free Survival
Medical Records
Retrospective Studies
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

@article{39776994244947baabdaf14b452fc7c9,
title = "Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity",
abstract = "Objectives: We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). Materials and methods: From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared. Results: The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2{\%} vs. 69.4{\%} (p = 0.079), respectively. The 3-year local-regional control (53.5{\%} vs. 76.3{\%}; p = 0.020) and disease-free survival rates (47.8{\%} vs. 70.0{\%}; p = 0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (≤2 mm), more advanced T stage (T3-4 vs. T1-2), and conventional RT method were associated with worse prognosis. Conclusions: The addition of chemotherapy to adjuvant radiotherapy is recommended in patients with above risk factors. Our result underscores that IMRT should be considered to apply to OSCC patients referred for postoperative treatment.",
author = "Chen, {Pang Yu} and Chen, {Helen H.W} and Jenn-Ren Hsiao and Ming-Wei Yang and Wei-Ting Hsueh and Tasi, {Sen Tien} and Forn-Chia Lin and Yuan-Hua Wu",
year = "2012",
month = "8",
day = "1",
doi = "10.1016/j.oraloncology.2012.02.010",
language = "English",
volume = "48",
pages = "747--752",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Intensity-modulated radiotherapy improves outcomes in postoperative patients with squamous cell carcinoma of the oral cavity

AU - Chen, Pang Yu

AU - Chen, Helen H.W

AU - Hsiao, Jenn-Ren

AU - Yang, Ming-Wei

AU - Hsueh, Wei-Ting

AU - Tasi, Sen Tien

AU - Lin, Forn-Chia

AU - Wu, Yuan-Hua

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Objectives: We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). Materials and methods: From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared. Results: The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2% vs. 69.4% (p = 0.079), respectively. The 3-year local-regional control (53.5% vs. 76.3%; p = 0.020) and disease-free survival rates (47.8% vs. 70.0%; p = 0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (≤2 mm), more advanced T stage (T3-4 vs. T1-2), and conventional RT method were associated with worse prognosis. Conclusions: The addition of chemotherapy to adjuvant radiotherapy is recommended in patients with above risk factors. Our result underscores that IMRT should be considered to apply to OSCC patients referred for postoperative treatment.

AB - Objectives: We compared the outcomes and survival rates of patients with oral cavity squamous cell carcinoma receiving postoperative conventional radiotherapy (RT) or intensity-modulated radiotherapy (IMRT). Materials and methods: From January 2005 to September 2008, medical records of 131 consecutive patients with oral cancer receiving postoperative radiotherapy in the Department of Radiation Oncology of National Cheng Kung University Hospital were reviewed. Patients were divided into two groups according to the administration of postoperative conventional RT or IMRT. The loco-regional control, survival, and other prognostic factors were compared. Results: The 3-year Kaplan-Meier estimates of overall survival for patients receiving conventional RT and IMRT groups were 51.2% vs. 69.4% (p = 0.079), respectively. The 3-year local-regional control (53.5% vs. 76.3%; p = 0.020) and disease-free survival rates (47.8% vs. 70.0%; p = 0.027) were significantly increased in the IMRT group. This retrospective study also identified that extracapsular spreading, margin positive/close (≤2 mm), more advanced T stage (T3-4 vs. T1-2), and conventional RT method were associated with worse prognosis. Conclusions: The addition of chemotherapy to adjuvant radiotherapy is recommended in patients with above risk factors. Our result underscores that IMRT should be considered to apply to OSCC patients referred for postoperative treatment.

UR - http://www.scopus.com/inward/record.url?scp=84864408545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864408545&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2012.02.010

DO - 10.1016/j.oraloncology.2012.02.010

M3 - Article

C2 - 22401870

AN - SCOPUS:84864408545

VL - 48

SP - 747

EP - 752

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 8

ER -