Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in heroin-dependent patients

Sheng Yu Lee, Tzu Yun Wang, Shiou Lan Chen, San Yuan Huang, Nian Sheng Tzeng, Yun Hsuan Chang, Chen Lin Wang, Yu Shan Wang, I. Hui Lee, Tzung Lieh Yeh, Yen Kuang Yang, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


OBJECTIVES: Heroin dependence is a multifactor disorder. We investigated the association of genetic factors and heroin-dependent temperaments to determine whether a temperament-gene interaction is involved in the pathogenesis of heroin dependence. METHODS: Three hundred seventy participants (259 heroin-dependent patients and 111 healthy controls) were recruited and finished the Tridimensional Personality Questionnaire to assess personality traits (temperament). The genotypes of the aldehyde dehydrogenase 2 (ALDH2) gene and the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene using polymerase chain reactions plus restriction fragment length polymorphism analysis. RESULTS: Multiple logistic regression analysis showed significant main effects for novelty seeking (P ≤ 0.001) and harm-avoidance (P = 0.001) scores, and a significant interaction effect between novelty seeking and ALDH2 genotypes (P = 0.016) in heroin-dependent patients compared with controls. When stratified by the ALDH2 genotypes, only heroin-dependent patients with the *1*2 and *2*2 genotypes at ALDH2 had higher novelty-seeking scores than did controls (heroin dependence = 15.94, controls = 12.46; P ≤ 0.001). CONCLUSIONS: Our results provide initial evidence that the ALDH2 gene interacted with novelty seeking in heroin-dependent Han Chinese patients in Taiwan.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalJournal of Clinical Psychopharmacology
Issue number3
Publication statusPublished - 2013 Jun

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)


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